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Title: Outcome of surgical and radiation therapy treatment of grade II meningiomas: A single institution experience
Other Titles: ผลการรักษาโรคเนื้องอกเยื่อหุ้มสมองระดับ 2 ด้วยการผ่าตัดและการฉายรังสีในสถาบันที่วิจัยเพียงสถาบันเดียว
Authors: Bongkot Jia-Mahasap
Salita Angkurawaranon
Songkiet Suwansirikul
Somvilai Chakrabandhu
Pitchayaponne Klunklin
Wimrak Onchan
Patumrat Sripan
Imjai Chitapanarux
Keywords: WHO grade II meningiomas
adjuvant radiation therapy
Issue Date: 2019
Publisher: Faculty of Medicine, Chiang Mai University
Citation: Chiang Mai Medical Journal 57, 3 (July-Sept 2019), 135-141
Abstract: Objective To evaluate local control and survival rates with two different treatment modalities: surgery alone and surgery plus adjuvant radiation therapy (RT). Methods Cases of 104 patients diagnosed with grade II meningiomas between 2004 and 2014 were retrospectively reviewed. Of those, 68 patients had complete medical records. For inclusion in this study, we required a follow-up period of more than 2 years. Age at diagnosis, initial tumor size, tumor location, extent of resection and adjuvant RT were categorized to identify possible parameters that may have affected the outcome of this disease. Result Thirty-seven patients (54%) received surgery alone while 31 patients (46%) received adjuvant RT. The 2-year and 5-year rates of local control (LC) were 94% and 87%, respectively. No correlation was found between other parameters and recurrence of tumors. Patients in our study who received adjuvant RT had signi fi cant lower overall survival rate (p=0.044). The 2-year overall survival (OS) was 99% and 5-year OS was 93%. Conclusion Tumor control and survival were found to be excellent in this retrospective study. Adjuvant RT did not in fl uence local control, but was statistically associated with lower survival rates. Further prospective study should be performed to clarify the management of grade II meningiomas.
Description: Chiang Mai Medical Journal (Formerly Chiang Mai Medical Bulletin) is an official journal of the Faculty of Medicine, Chiang Mai University. It accepts original papers on clinical and experimental research that are pertinent in the biomedical sciences. The Journal is published 4 issues/year (i.e., Mar, Jun, Sep, and Dec).
ISSN: 0125-5983
Appears in Collections:CMUL: Journal Articles

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