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dc.contributor.authorStephane Wen Wei Kuen_US
dc.contributor.authorAwachana Jiamsakulen_US
dc.contributor.authorKedar Joshien_US
dc.contributor.authorMark Kristoffer Ungos Pasayanen_US
dc.contributor.authorAlvina Widhanien_US
dc.contributor.authorRomanee Chaiwarithen_US
dc.contributor.authorSasisopin Kiertiburanakulen_US
dc.contributor.authorAnchalee Avihingsanonen_US
dc.contributor.authorPenh Sun Lyen_US
dc.contributor.authorNagalingeswaran Kumarasamyen_US
dc.contributor.authorCuong D. Doen_US
dc.contributor.authorTuti P. Meratien_US
dc.contributor.authorKinh Van Nguyenen_US
dc.contributor.authorAdeeba Kamarulzamanen_US
dc.contributor.authorFujie Zhangen_US
dc.contributor.authorMan Po Leeen_US
dc.contributor.authorJun Yong Choien_US
dc.contributor.authorJunko Tanumaen_US
dc.contributor.authorSuwimon Khusuwanen_US
dc.contributor.authorBenedict Lim Heng Simen_US
dc.contributor.authorOon Tek Ngen_US
dc.contributor.authorWinai Ratanasuwanen_US
dc.contributor.authorJeremy Rossen_US
dc.contributor.authorWing Wai Wongen_US
dc.contributor.authorP. S. Lyen_US
dc.contributor.authorV. Kholen_US
dc.contributor.authorF. J. Zhangen_US
dc.contributor.authorH. X. Zhaoen_US
dc.contributor.authorN. Hanen_US
dc.contributor.authorM. P. Leeen_US
dc.contributor.authorP. C.K. Lien_US
dc.contributor.authorW. Lamen_US
dc.contributor.authorY. T. Chanen_US
dc.contributor.authorN. Kumarasamyen_US
dc.contributor.authorS. Saghayamen_US
dc.contributor.authorC. Ezhilarasien_US
dc.contributor.authorS. Pujarien_US
dc.contributor.authorK. Joshien_US
dc.contributor.authorS. Gaikwaden_US
dc.contributor.authorA. Chitalikaren_US
dc.contributor.authorS. Sangleen_US
dc.contributor.authorV. Maveen_US
dc.contributor.authorI. Marbaniangen_US
dc.contributor.authorD. N. Wirawanen_US
dc.contributor.authorF. Yulianaen_US
dc.contributor.authorE. Yunihastutien_US
dc.contributor.authorD. Imranen_US
dc.contributor.authorJ. Tanumaen_US
dc.contributor.authorS. Okaen_US
dc.contributor.authorT. Nishijimaen_US
dc.contributor.authorJ. Y. Choien_US
dc.contributor.authorS. Naen_US
dc.contributor.authorJ. M. Kimen_US
dc.contributor.authorB. L.H. Simen_US
dc.contributor.authorY. M. Ganien_US
dc.contributor.authorN. B. Rudien_US
dc.contributor.authorA. Kamarulzamanen_US
dc.contributor.authorS. F. Syed Omaren_US
dc.contributor.authorS. Ponnampalavanaren_US
dc.contributor.authorI. Azwaen_US
dc.contributor.authorR. Ditangcoen_US
dc.contributor.authorM. L. Mationgen_US
dc.contributor.authorW. W. Wongen_US
dc.contributor.authorS. W.W. Kuen_US
dc.contributor.authorP. C. Wuen_US
dc.contributor.authorO. T. Ngen_US
dc.contributor.authorP. L. Limen_US
dc.contributor.authorL. S. Leeen_US
dc.contributor.authorZ. Ferdousen_US
dc.contributor.authorA. vihingsanonen_US
dc.contributor.authorS. Gatechompolen_US
dc.contributor.authorP. Phanuphaken_US
dc.contributor.authorC. Phadungphonen_US
dc.contributor.authorS. Kiertiburanakulen_US
dc.contributor.authorA. Phuphuakraten_US
dc.contributor.authorL. Chumlaen_US
dc.contributor.authorN. Sanmeemaen_US
dc.contributor.authorR. Chaiwarithen_US
dc.contributor.authorT. Sirisanthanaen_US
dc.contributor.authorW. Kotarathititumen_US
dc.contributor.authorJ. Praparattanapanen_US
dc.contributor.authorS. Khusuwanen_US
dc.contributor.authorP. Kantipongen_US
dc.contributor.authorP. Kambuaen_US
dc.contributor.authorW. Ratanasuwanen_US
dc.contributor.authorR. Sriondeeen_US
dc.contributor.authorK. V. Nguyenen_US
dc.contributor.authorH. V. Buien_US
dc.contributor.authorD. T.H. Nguyenen_US
dc.contributor.authorD. T. Nguyenen_US
dc.contributor.authorC. D. Doen_US
dc.contributor.authorA. V. Ngoen_US
dc.contributor.authorL. T. Nguyenen_US
dc.contributor.authorA. H. Sohnen_US
dc.contributor.authorJ. L. Rossen_US
dc.contributor.authorB. Petersenen_US
dc.contributor.authorD. A. Cooperen_US
dc.contributor.authorM. G. Lawen_US
dc.date.accessioned2019-08-05T04:41:06Z-
dc.date.available2019-08-05T04:41:06Z-
dc.date.issued2019-03-01en_US
dc.identifier.issn17582652en_US
dc.identifier.other2-s2.0-85063688788en_US
dc.identifier.other10.1002/jia2.25264en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063688788&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/65786-
dc.description.abstract© 2019 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society. Introduction: Cotrimoxazole (CTX) is recommended as prophylaxis against Pneumocystis jiroveci pneumonia, malaria and other serious bacterial infections in HIV-infected patients. Despite its in vitro activity against Mycobacterium tuberculosis, the effects of CTX preventive therapy on tuberculosis (TB) remain unclear. Methods: Adults living with HIV enrolled in a regional observational cohort in Asia who had initiated combination antiretroviral therapy (cART) were included in the analysis. Factors associated with new TB diagnoses after cohort entry and survival after cART initiation were analysed using Cox regression, stratified by site. Results: A total of 7355 patients from 12 countries enrolled into the cohort between 2003 and 2016 were included in the study. There were 368 reported cases of TB after cohort entry with an incidence rate of 0.99 per 100 person-years (/100 pys). Multivariate analyses adjusted for viral load (VL), CD4 count, body mass index (BMI) and cART duration showed that CTX reduced the hazard for new TB infection by 28% (HR 0.72, 95% CI l 0.56, 0.93). Mortality after cART initiation was 0.85/100 pys, with a median follow-up time of 4.63 years. Predictors of survival included age, female sex, hepatitis C co-infection, TB diagnosis, HIV VL, CD4 count and BMI. Conclusions: CTX was associated with a reduction in the hazard for new TB infection but did not impact survival in our Asian cohort. The potential preventive effect of CTX against TB during periods of severe immunosuppression should be further explored.en_US
dc.subjectMedicineen_US
dc.titleCotrimoxazole prophylaxis decreases tuberculosis risk among Asian patients with HIVen_US
dc.typeJournalen_US
article.title.sourcetitleJournal of the International AIDS Societyen_US
article.volume22en_US
article.stream.affiliationsHospital Sungai Bulohen_US
article.stream.affiliationsBeijing Ditan Hospitalen_US
article.stream.affiliationsVHS Medical Centre Indiaen_US
article.stream.affiliationsGokilaen_US
article.stream.affiliationsBach Mai Hospitalen_US
article.stream.affiliationsUniversitas Udayanaen_US
article.stream.affiliationsUniversity of Indonesia, RSUPN Dr. Cipto Mangunkusumoen_US
article.stream.affiliationsUniversity of New South Wales (UNSW) Australiaen_US
article.stream.affiliationsChulalongkorn Universityen_US
article.stream.affiliationsTaipei City Hospital Taiwanen_US
article.stream.affiliationsNational Center for Global Health and Medicineen_US
article.stream.affiliationsYonsei University College of Medicineen_US
article.stream.affiliationsFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
article.stream.affiliationsQueen Elizabeth Hospital Hong Kongen_US
article.stream.affiliationsUniversity of Malaya Medical Centreen_US
article.stream.affiliationsVeterans General Hospital-Taipeien_US
article.stream.affiliationsFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
article.stream.affiliationsTan Tock Seng Hospitalen_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsDermatology & STDs and University of Health Sciencesen_US
article.stream.affiliationsNational Hospital for Tropical Diseasesen_US
article.stream.affiliationsFoundation for AIDS Researchen_US
article.stream.affiliationsInstitute of Infectious Diseasesen_US
article.stream.affiliationsChiangrai Prachanukroh Hospitalen_US
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