Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/65728
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dc.contributor.authorSiriwan Tangjitgamolen_US
dc.contributor.authorEkkasit Tharavichitkulen_US
dc.contributor.authorChokaew Tovanabutraen_US
dc.contributor.authorKanisa Rongsriyamen_US
dc.contributor.authorTussawan Asakijen_US
dc.contributor.authorKannika Paengchiten_US
dc.contributor.authorJirasak Sukhaboonen_US
dc.contributor.authorSomkit Penpattanagulen_US
dc.contributor.authorApiradee Kridakaraen_US
dc.contributor.authorJitti Hanprasertpongen_US
dc.contributor.authorKittisak Chompraserten_US
dc.contributor.authorSirentra Wanglikitkoonen_US
dc.contributor.authorThiti Atjimakulen_US
dc.contributor.authorPiyawan Pariyawateekulen_US
dc.contributor.authorKanyarat Katanyooen_US
dc.contributor.authorPrapai Tanpraserten_US
dc.contributor.authorWanwipa Janweerachaien_US
dc.contributor.authorDuangjai Sangthawanen_US
dc.contributor.authorJakkapan Khunnarongen_US
dc.contributor.authorTaywin Chottetanaprasithen_US
dc.contributor.authorBusaba Supawattanabodeeen_US
dc.contributor.authorPrasert Lertsanguansinchaien_US
dc.contributor.authorJatupol Srisomboonen_US
dc.contributor.authorWanrudee Isaranuwatchaien_US
dc.contributor.authorVichan Lorvidhayaen_US
dc.date.accessioned2019-08-05T04:40:09Z-
dc.date.available2019-08-05T04:40:09Z-
dc.date.issued2019-07-01en_US
dc.identifier.issn20050399en_US
dc.identifier.issn20050380en_US
dc.identifier.other2-s2.0-85067267222en_US
dc.identifier.other10.3802/jgo.2019.30.e82en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067267222&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/65728-
dc.description.abstract© 2019. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology. Objective: To compare response rate and survivals of locally advanced stage cervical cancer patients who had standard concurrent chemoradiation therapy (CCRT) alone to those who had adjuvant chemotherapy (ACT) after CCRT. Methods: Patients aged 18–70 years who had International Federation of Gynecology and Obstetrics stage IIB–IVA without para-aortic lymph node enlargement, Eastern Cooperative Oncology Group scores 0–2, and non-aggressive histopathology were randomized to have CCRT with weekly cisplatin followed by observation (arm A) or by ACT with paclitaxel plus carboplatin every 4 weeks for 3 cycles (arm B). Results: Data analysis of 259 patients showed no significant difference in complete responses at 4 months after treatment between arm A (n=129) and arm B (n=130): 94.1% vs. 87.0% (p=0.154) respectively. With the median follow-up of 27.4 months, 15.5% of patients in arm A and 10.8% in arm B experienced recurrences (p=0.123). There were no significant differences of overall or loco-regional failure. However, systemic recurrences were significantly lower in arm B than arm A: 5.4% vs. 10.1% (p=0.029). The 3-year progression-free survival (PFS) and 3-year overall survival (OS) of the patients in both arms were not significantly different. The hazard ratio of PFS and OS of arm B compared to arm A were 1.26 (95% CI=0.82–1.96; p=0.293) and 1.42 (95% CI=0.81–2.49; p=0.221) respectively. Conclusions: ACT with paclitaxel plus carboplatin after CCRT did not improve response rate and survival compared to CCRT alone. Only significant decrease of systemic recurrences with ACT was observed, but not overall or loco-regional failure.en_US
dc.subjectMedicineen_US
dc.titleA randomized controlled trial comparing concurrent chemoradiation versus concurrent chemoradiation followed by adjuvant chemotherapy in locally advanced cervical cancer patients: ACTLACC trialen_US
dc.typeJournalen_US
article.title.sourcetitleJournal of Gynecologic Oncologyen_US
article.volume30en_US
article.stream.affiliationsBhumibol Adulyadej Hospitalen_US
article.stream.affiliationsKing Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn Universityen_US
article.stream.affiliationsVajira Hospitalen_US
article.stream.affiliationsSaint Michael's Hospital University of Torontoen_US
article.stream.affiliationsPrince of Songkla Universityen_US
article.stream.affiliationsRajavithi Hospitalen_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsUbon Ratchathani Cancer Hospitalen_US
article.stream.affiliationsUdonthani Cancer Hospitalen_US
article.stream.affiliationsLampang Cancer Hospitalen_US
article.stream.affiliationsLopburi Cancer Hospitalen_US
article.stream.affiliationsChonburi Cancer Hospitalen_US
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