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dc.contributor.authorWoottichai Khamduangen_US
dc.contributor.authorNichagamon Ponchomcheunen_US
dc.contributor.authorWitchuda Yaaupalaen_US
dc.contributor.authorPhongpatchara Puwaruengpaten_US
dc.contributor.authorSayamon Hongjaiseeen_US
dc.contributor.authorTanawan Samleeraten_US
dc.contributor.authorJintana Yanolaen_US
dc.contributor.authorSakorn Pornpraserten_US
dc.contributor.authorKwanchai Ratanasthienen_US
dc.contributor.authorGonzague Jourdainen_US
dc.contributor.authorNicole Ngo-Giang-Huongen_US
dc.contributor.authorWasna Sirirungsien_US
dc.description.abstract© 2019 Khamduang et al. Introduction: Thailand has integrated hepatitis B (HB) vaccination of newborns into the national Expanded Program on Immunization (EPI) in 1992. This has led to a dramatic decrease of HBsAg prevalence in children. However, HB vaccine coverage in remote areas is not well-known. This study aimed to investigate serologic characteristics of hepatitis B virus (HBV) among hill-tribe children in Omkoi District, Chiangmai Province, Thailand. Methodology: This cross-sectional study was conducted on stored samples collected from hill-tribe children attending the primary/secondary school in Omkoi District in December 2014. Sera were tested for HBsAg, anti-HBs and anti-HBc using enzyme immunoassays (MUREX, DiaSorin, Italy). Samples with anti-HBc positive were further assessed for HBV DNA using an in-house HBV DNA semi-nested polymerase chain reaction (PCR) assay. Results: Of 210 children evaluated, 4 (1.9%:95% CI 0.5-4.8) were HBsAg-positive. Of the 206 children HBsAg negative, 17 were anti-HBc and anti-HBs positive, 15 anti-HBc positive only, 26 anti-HBs positive only and 148 negative for both anti-HBc and anti-HBs. None of the children with anti-HBc were positive for HBV DNA. Conclusions: A high percentage of children had no markers of HBV protection suggesting that HB vaccine coverage was not optimal in this area. Our results warrant HBV serologic investigations in other remote areas to assess whether HB vaccine coverage needs to be improved and to identify children who should be vaccinated.en_US
dc.subjectImmunology and Microbiologyen_US
dc.titleSerologic characteristics of hepatitis B virus among hill-tribe children in Omkoi district, Chiangmai province, Thailanden_US
article.title.sourcetitleJournal of Infection in Developing Countriesen_US
article.volume13en_US School of Public Healthen_US Mai Universityen_USé Mixte Internationale 174-PHPTen_US
Appears in Collections:CMUL: Journal Articles

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