Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/65607
Title: Evaluation the effects of Cissus modeccoides hot aqueous extract on alloxan-induced diabetic rats
Authors: Waranee Pradit
Taddaow Khumpook
Kanokporn Saenphet
Supap Saenphet
Siriwadee Chomdej
Keywords: Engineering
Medicine
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2019
Abstract: © 2019 Journal of Reports in Pharmaceutical Sciences. Introduction: In this study, the hypoglycemic effects and the safety of Cissus modeccoides (CM) were assessed on alloxan-induced diabetic rats. Methods: Various concentrations of CM hot aqueous extract were orally administered to alloxan-induced diabetic rats for 30 days. Blood glucose level, hematological and biochemical parameters, and gene expression level were evaluated. Results: After CM treatment, diabetic rats presented nonreduced blood glucose level and unimproved body weight. Increased blood urea nitrogen was observed in CM-treated groups as well. Although hematological parameters and cholesterol level revealed nonsignificant effects from CM, decreased expression levels of the insulin receptor in the pancreas and insulin receptor substrate 2 and glucose transporter 2 in the liver were demonstrated in CM-treated groups. Nephrin in the kidney of CM groups was highly expressed. Conclusion: The results of this study revealed adverse effects and toxicity of CM extracts in diabetic rats.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063726984&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/65607
ISSN: 23225106
23221232
Appears in Collections:CMUL: Journal Articles

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