Please use this identifier to cite or link to this item:
|Title:||Highly diastereoselective synthesis of enantioenriched: Anti -α-allyl-β-fluoroamines|
|Authors:||Philip J. Chevis|
Anthony W. Carroll
Anthony C. Willis
Stephen G. Pyne
|Abstract:||© 2019 The Royal Society of Chemistry. A highly diastereoselective synthesis of anti-α-allyl-β-fluoroamines has been developed involving enantioselective α-fluorination of aldehydes followed by a diastereoselective Petasis allyl borono-Mannich reaction. The products are obtained generally in good overall yields for the two steps and with drs of 97:3-99:1 and ees of 86-92%. Selected products were converted to 3-, 5- and 6-membered ring heterocycles, the latter two types incorporating an exo-cyclic fluorine.|
|Appears in Collections:||CMUL: Journal Articles|
Files in This Item:
There are no files associated with this item.
Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.