Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/63841
Title: Three New Polycyclic Containing Sulfur Compounds from the Seeds of Combretum quadrangulare Kurz (Combretaceae), Antifungal and Anti-mycobacterium activities
Authors: Khesorn Nantachit
Sasithorn Sirilun
Saksit Nobsathian
Somjing Rungjang
Authors: Khesorn Nantachit
Sasithorn Sirilun
Saksit Nobsathian
Somjing Rungjang
Issue Date: 2017
Publisher: Science Faculty of Chiang Mai University
Abstract: Three new polycyclic containing sulfur compounds, Combretanoid, Combretanane and Combretanun, were isolated. The crude ethanolic extract and pure compound Combretin, the isolated pure compound from the seeds of Combretum quadrangulare Kurz (Combretaceae), showed antimicrobial activities against many pathogens. The aim of this study was to determine antifungal activity against opportunistic pathogens in HIV patients and anti-mycobacterium tuberculosis activity (anti-TB). An Antifungal test was performed by agar dilution method and an anti-TB test was done using green fluorescent protein microplate assay (GFPMA). Crude ethanolic extract from Amphur Sun Srai showed antifungal activity against A. fumigatus better than the extract from Amphur Sarapee. Combretanoid showed no antifungal activity and the three new compounds showed no anti-TB activity. This plant showed no toxicity to albino rat and mice. In conclusion, it may used as a traditional method for antifungal activity against A. fumigatus.
URI: http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=7668
http://cmuir.cmu.ac.th/jspui/handle/6653943832/63841
ISSN: 0125-2526
Appears in Collections:CMUL: Journal Articles

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