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dc.contributor.authorR. Bijkeren_US
dc.contributor.authorA. Jiamsakulen_US
dc.contributor.authorE. Uyen_US
dc.contributor.authorN. Kumarasamyen_US
dc.contributor.authorR. Ditangoen_US
dc.contributor.authorR. Chaiwarithen_US
dc.contributor.authorW. W. Wongen_US
dc.contributor.authorA. Avihingsanonen_US
dc.contributor.authorL. P. Sunen_US
dc.contributor.authorE. Yunihastutien_US
dc.contributor.authorS. Pujarien_US
dc.contributor.authorC. D. Doen_US
dc.contributor.authorT. P. Meratien_US
dc.contributor.authorP. Kantipongen_US
dc.contributor.authorK. V. Nguyenen_US
dc.contributor.authorA. Kamarulzamanen_US
dc.contributor.authorF. Zhangen_US
dc.contributor.authorM. P. Leeen_US
dc.contributor.authorJ. Y. Choien_US
dc.contributor.authorJ. Tanumaen_US
dc.contributor.authorO. T. Ngen_US
dc.contributor.authorB. L.H. Simen_US
dc.contributor.authorJ. Rossen_US
dc.contributor.authorS. Kiertiburanakulen_US
dc.contributor.authorP. S. Lyen_US
dc.contributor.authorR. Ditangcoen_US
dc.contributor.authorD. D. Cuongen_US
dc.contributor.authorA. H. Sohnen_US
dc.contributor.authorM. G. Lawen_US
dc.description.abstract© 2019 British HIV Association Objectives: With aging of the HIV-positive population, cardiovascular disease (CVD) increasingly contributes to morbidity and mortality. We investigated CVD-related and other causes of death (CODs) and factors associated with CVD in a multi-country Asian HIV-positive cohort. Methods: Patient data from 2003–2017 were obtained from the Therapeutics, Research, Education and AIDS Training in Asia (TREAT Asia) HIV Observational Database (TAHOD). We included patients on antiretroviral therapy (ART) with > 1 day of follow-up. Cumulative incidences were plotted for CVD-related, AIDS-related, non-AIDS-related, and unknown CODs, and any CVD (i.e. fatal and nonfatal). Competing risk regression was used to assess risk factors of any CVD. Results: Of 8069 patients with a median follow-up of 7.3 years [interquartile range (IQR) 4.4–10.7 years], 378 patients died [incidence rate (IR) 6.2 per 1000 person-years (PY)], and this total included 22 CVD-related deaths (IR 0.36 per 1000 PY). Factors significantly associated with any CVD event (IR 2.2 per 1000 PY) were older age [sub-hazard ratio (sHR) 2.21; 95% confidence interval (CI) 1.36–3.58 for age 41–50 years; sHR 5.52; 95% CI 3.43–8.91 for ≥ 51 years, compared with < 40 years], high blood pressure (sHR 1.62; 95% CI 1.04–2.52), high total cholesterol (sHR 1.89; 95% CI 1.27–2.82), high triglycerides (sHR 1.55; 95% CI 1.02–2.37) and high body mass index (BMI) (sHR 1.66; 95% CI 1.12–2.46). CVD crude IRs were lower in the later ART initiation period and in lower middle- and upper middle-income countries. Conclusions: The development of fatal and nonfatal CVD events in our cohort was associated with older age, and treatable risk factors such as high blood pressure, triglycerides, total cholesterol and BMI. Lower CVD event rates in middle-income countries may indicate under-diagnosis of CVD in Asian-Pacific resource-limited settings.en_US
dc.titleCardiovascular disease-related mortality and factors associated with cardiovascular events in the TREAT Asia HIV Observational Database (TAHOD)en_US
article.title.sourcetitleHIV Medicineen_US
article.volume20en_US of New South Wales (UNSW) Australiaen_US Medical Centre Indiaen_US Mai Universityen_US General Hospital-Taipeien_US HIV Netherlands Australia Thailand Research Collaborationen_US of Health Sciencesen_US of Indonesia, RSUPN Dr. Cipto Mangunkusumoen_US of Infectious Diseasesen_US Mai Hospitalen_US Udayanaen_US Prachanukroh Hospitalen_US Hospital for Tropical Diseasesen_US of Malaya Medical Centreen_US Ditan Hospitalen_US Elizabeth Hospital Hong Kongen_US University College of Medicineen_US Center for Global Health and Medicineen_US Tock Seng Hospitalen_US Sungai Bulohen_US for AIDS Researchen_US Universityen_US
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