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dc.contributor.authorSiripong Paleeen_US
dc.contributor.authorWanitchaya Mintaen_US
dc.contributor.authorDuangkamol Mantoren_US
dc.contributor.authorWissuta Suthamen_US
dc.contributor.authorThidarat Jaiwongkamen_US
dc.contributor.authorSasiwan Kerdphooen_US
dc.contributor.authorWasana Pratchayasakulen_US
dc.contributor.authorSiriporn C. Chattipakornen_US
dc.contributor.authorNipon Chattipakornen_US
dc.description.abstract© 2019 Elsevier Inc. Background: Long-term high-fat diet (HFD) consumption causes obese-insulin resistance which is known to be a major risk factor for cardiovascular diseases due to its impact on the impairment of left ventricular (LV) contractile function and cardiac mitochondrial function. Intracellular calcium [Ca 2+ ]i regulation plays an important role in the maintenance of LV function. Although either caloric restriction (CR) or exercise (Ex) are shown to strongly affect metabolic status and LV function, the combined effects of exercise and calorie restriction on cardiometabolic status, cardiac mitochondrial dynamics and cardiac [Ca 2+ ]i transient homeostasis under conditions of obese-insulin resistance have never been investigated. Methods: Female rats were fed with either a high-fat diet (HFD: fat, 59.28%; protein, 26.45%; carbohydrate, 14.27%) or a normal diet (fat, 19.77%; protein, 28.24%; carbohydrate, 51.99%) for 13 weeks. HFD rats were then divided into 4 groups: 1) Vehicle (HFD + Veh); 2) Calorie restriction (HFD + CR); 3) Exercise (HFD + Ex) and 4) Combined therapy (HFD + CR + Ex). After 6-week intervention, the metabolic status, heart rate variability (HRV), LV function, cardiac mitochondrial dynamics, and [Ca 2+ ]i transients were determined. Results: Insulin resistance developed in HFD rats as indicated by increased plasma insulin and HOMA index. Although HFD + Veh rats had markedly impaired LV function, indicated by reduced %LVFS and impaired cardiac mitochondrial dynamics and [Ca 2+ ]i transients, these impairments were attenuated in the HFD + CR, HFD + Ex and HFD + CR + Ex rats. However, the greatest improvement in cardiometabolic function was observed in HFD + CR + Ex rats. Conclusions: Our findings indicated that a combination of calorie restriction and exercise exerted greater cardioprotection than a monotherapy through the improvement of cardiometabolic status, cardiac mitochondrial dynamics and cardiac [Ca 2+ ]i homeostasis in obese-insulin resistant rats.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleCombination of exercise and calorie restriction exerts greater efficacy on cardioprotection than monotherapy in obese-insulin resistant rats through the improvement of cardiac calcium regulationen_US
article.title.sourcetitleMetabolism: Clinical and Experimentalen_US
article.volume94en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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