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Title: | Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis |
Authors: | Chiramet Auranwiwat Roonglawan Rattanajak Sumalee Kamchonwongpaisan Surat Laphookhieo Stephen G. Pyne Thunwadee Limtharakul |
Authors: | Chiramet Auranwiwat Roonglawan Rattanajak Sumalee Kamchonwongpaisan Surat Laphookhieo Stephen G. Pyne Thunwadee Limtharakul |
Keywords: | Pharmacology, Toxicology and Pharmaceutics |
Issue Date: | 1-Oct-2018 |
Abstract: | © 2018 Elsevier B.V. The phytochemical investigation of the fruit extracts of Uvaria cherrevensis led to the isolation and characterization of four new C-benzyl flavonoids; cherrevenones A-D (1–4) together with 11 known compounds. The isolated compounds were characterized using spectroscopic techniques. Compounds 1, 3, 5 and 11 showed moderate inhibitory activities against the P. falciparum strains TM4/8.2 and K1CB1 with IC50 values ranging from 21.0 ± 3.10 – 33.7 ± 7.69 and 21.0 ± 5.44 – 43.5 ± 11.9 μM, respectively. Compounds 1, 2, 5, 10 and 11 exhibited strong cytotoxic activities against KB cells with IC50 values ranging from 0.60 ± 0.17 – 4.91 ± 2.69 μM which were similar to their cytotoxic activities found against Vero cells, except for compound 5, which was non-toxic to Vero cells. |
URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85053160199&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62867 |
ISSN: | 18736971 0367326X |
Appears in Collections: | CMUL: Journal Articles |
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