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Title: Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis
Authors: Chiramet Auranwiwat
Roonglawan Rattanajak
Sumalee Kamchonwongpaisan
Surat Laphookhieo
Stephen G. Pyne
Thunwadee Limtharakul
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Oct-2018
Abstract: © 2018 Elsevier B.V. The phytochemical investigation of the fruit extracts of Uvaria cherrevensis led to the isolation and characterization of four new C-benzyl flavonoids; cherrevenones A-D (1–4) together with 11 known compounds. The isolated compounds were characterized using spectroscopic techniques. Compounds 1, 3, 5 and 11 showed moderate inhibitory activities against the P. falciparum strains TM4/8.2 and K1CB1 with IC50 values ranging from 21.0 ± 3.10 – 33.7 ± 7.69 and 21.0 ± 5.44 – 43.5 ± 11.9 μM, respectively. Compounds 1, 2, 5, 10 and 11 exhibited strong cytotoxic activities against KB cells with IC50 values ranging from 0.60 ± 0.17 – 4.91 ± 2.69 μM which were similar to their cytotoxic activities found against Vero cells, except for compound 5, which was non-toxic to Vero cells.
ISSN: 18736971
Appears in Collections:CMUL: Journal Articles

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