Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454)

Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/62352

Title:	Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454)
Authors:	Jun Ichiro Sekiguchi Prasit Tharavichitkul Tohru Miyoshi-Akiyama Vena Chupia Tomoko Fujino Minako Araake Atsushi Irie Koji Morita Tadatoshi Kuratsuji Teruo Kirikae
Authors:	Jun Ichiro Sekiguchi Prasit Tharavichitkul Tohru Miyoshi-Akiyama Vena Chupia Tomoko Fujino Minako Araake Atsushi Irie Koji Morita Tadatoshi Kuratsuji Teruo Kirikae
Keywords:	Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date:	1-Sep-2005
Abstract:	A novel gene, dfrG, encoding a trimethoprim (TMP)-resistant dihydrofolate reductase (DHFR, designated S3DHFR) was cloned from a clinical isolate of methicillin-resistant Staphylococcus aureus. Escherichia coli expressing dfrG was highly resistant to TMP. Recombinant S3DHFR exhibited DHFR activity that was not inhibited by TMP. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
URI:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=24144502081&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62352
ISSN:	00664804
Appears in Collections:	CMUL: Journal Articles

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