Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/62153
Title: Review on screening and analysis techniques for hemoglobin variants and thalassemia
Authors: Supaporn Kradtap Hartwell
Boonraksa Srisawang
Prachya Kongtawelert
Gary D. Christian
Kate Grudpan
Keywords: Chemistry
Issue Date: 15-Mar-2005
Abstract: Thalassemia involves gene mutation that causes the production of an insufficient amount of normal structure globin chains while Hb variant involves gene mutation that causes the change in type or number of amino acid of the globin chain. It has been reported that some 200 million people worldwide had hemoglobinopathies of some sort. Attempts to develop effective and economical techniques for screening and analysis of thalassemia and Hb variants have become very important. In this review, we report the different techniques available, ranging from initial screening to extensive analysis, comparing advantages and disadvantages. Some indirect studies related to thalassemia indication and treatment follow-up are also included. We hope that information on these various techniques would be useful for some scientists who are working on development of a new technique or improving the existing ones. © 2004 Elsevier B.V. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=14844337894&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62153
ISSN: 00399140
Appears in Collections:CMUL: Journal Articles

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