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dc.contributor.authorChollada Kulwaten_US
dc.contributor.authorNirush Lertprasertsukeen_US
dc.contributor.authorPranee Leechanachaien_US
dc.contributor.authorPrachya Kongtawelerten_US
dc.contributor.authorUsanee Vinitketkumnuenen_US
dc.description.abstractThe hot water extract of the herbal tea, Gynostemma pentaphyllum Makino, was not found to be mutagenic in Salmonella mutation assay with or without metabolic activation. However, the extract had both DT-diaphorase inducing activity in the murine hepatoma (Hepa1c1c7) cell line and antimutagenic properties towards chemical-induced mutation in Salmonella typhimurium strains TA98 and TA1OO. Mutagenicity of aflatoxinB1 (AFB1),2-amino-6- methyldipyrido [1,2-a:3',2',3-d] imidazole (Glu-P-1), 2-aminodipyrido [1,2-a:3',2',3-d] imidazole (Glu-P-2), 2-amino-1, 4-dimethyl-5H-pyrido [4,3-b] indole (Trp-P-1), 3-amino-1-methyl-5H-pyrido [4,3-b] indole (Trp-P-2), 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) and Benzo [a] pyrene (B[a]P) was inhibited by the extract of Gynostemma pentaphyllum Makino in a dose-dependent manner, but no effect was found on the mutagenic activity of 2-(2-Furyl)-3-(5-nitro-2-furyl) acrylamide (AF-2). However, the extract enhanced the mutagenicity induced by 2-aminoanthracene (2AA), and N-methyl-N'-nitro-N- nitrosoguanidine (MNNG).en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleAntimutagenicity and DT-diaphorase inducing activity of Gynostemma pentaphyllum Makino extracten_US
article.title.sourcetitleJournal of Medical Investigationen_US
article.volume52en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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