Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/61791
Title: Helicobacter pylori infection in combination with the serum pepsinogen I/ II ratio and interleukin-1β-511 polymorphisms are independent risk factors for gastric cancer in Thais
Authors: Sirikan Yamada
Takeshi Matsuhisa
Luksana Makonkawkeyoon
Suparp Chaidatch
Shunji Kato
Norio Matsukura
Keywords: Medicine
Issue Date: 1-Dec-2006
Abstract: Background: Thailand has the lowest incidence of gastric cancer in the world. Helicobacter pylori infection, a low serum pepsinogen I/II ratio, and interleukin (IL)-1β-511 polymorphisms are suspected to be risk factors for gastric cancer. Methods: A total of 167 Thais, comprising 56 cancer patients and 111 volunteers without cancer, underwent an esophagogastroduodenoscopic examination and three fixed-point biopsies; a cancer tissue biopsy was also done, and blood samples were collected. The subjects without cancer were divided into normal subjects and chronic gastritis patients. IL-1β-511 polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism, and the serum levels of pepsinogen I and II were determined by a radioimmunoassay. Helicobacter pylori IgG antibody and tissue pathology were tested in all groups. Results: The pepsinogen I/II ratio was significantly lower in the gastric cancer group than in the normal and chronic gastritis groups [odds ratio (OR), 2.3; 95% confidence interval (CI), 1.10-4.80; P = 0.025]. Gastric cancer patients were positive for the H. pylori IgG antibody more frequently than negative (OR, 2.946; 95% CI, 1.4-6.39; P = 0.005). However, only 15 (27%) cancer patients were both positive for H. pylori IgG antibody and had low serum pepsinogen I/II. The C/C genotype was found more frequently in the gastric cancer group than in the group with a normal gastric mucosa (OR, 0.64; 95% CI, 0.50-0.81; P = 0.014). Conclusions: A low serum pepsinogen I/II ratio combined with positivity for H. pylori IgG, and a IL-1β-511 C/C genotype may be independent risk factors for gastric cancer in Thais. © Springer-Verlag Tokyo 2006.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33947585198&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/61791
ISSN: 14355922
09441174
Appears in Collections:CMUL: Journal Articles

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