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Title: Thermodynamics of the encapsulation by cyclodextrins
Authors: Suporn Charumanee
Aurawan Titwan
Jakkapan Sirithunyalug
Petra Weiss-Greiler
Peter Wolschann
Helmut Viemstein
Siriporn Okonogi
Keywords: Biochemistry, Genetics and Molecular Biology
Chemical Engineering
Environmental Science
Issue Date: 1-Apr-2006
Abstract: Molecular encapsulation on a molecular basis can be performed by cyclodextrins. The inclusion of organic molecules into the interior changes the properties of these molecules, which may be used for a broad variety of applications. The affinity of guest molecules for the cavities of various cyclodextrins depends on the stereochemistry and on the interaction forces of the molecules involved. Calculations of the thermodynamic parameters show that the reaction entropy is highly important for the inclusion reaction. Completely different reaction mechanisms are observed for various types of cyclodextrins as some of these reactions show enthalpy-entropy compensation. Others are supported by the reaction entropy or are even entropically controlled. Protonation and deprotonation reactions contribute significantly to the inclusion reaction, as first of all the solubility of the compounds in water is strongly influenced by the acidity of the solution, and, moreover, all tautomeric forms of the compounds show different affinities to various cyclodextrins. © 2006 Society of Chemical Industry.
ISSN: 10974660
Appears in Collections:CMUL: Journal Articles

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