Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/61414
Title: Acute and subchronic toxicity study of the water extract from root of Imperata cylindrica (Linn.) Raeusch. in rats
Authors: Siharat Chunlaratthanaphorn
Nirush Lertprasertsuke
Umarat Srisawat
Amornnat Thuppia
Anongnad Ngamjariyawat
Nadthaganya Suwanlikhid
Kanjana Jaijoy
Keywords: Multidisciplinary
Issue Date: 1-Mar-2007
Abstract: The water extract from root of Imperata cylindrica (Linn.) Raeusch. was studied for acute and subchronic toxicities. The extract at a single dose of 5,000 mg/kg was administered orally to female and male rats (5 male, 5 female). After 14 days, signs and behavioral changes, mortality, gross and histopathological changes of internal organs were examined. The extract did not produce signs of toxicity. For the subchronic toxicity test, the extract at doses of 300, 600 and 1,200 mg/kg body weight was orally administered to rats daily for 90 days (10 male, 10 female). The observation of signs, behavior and health status showed no abnormality in the test groups as compared with the controls. At the end of the study, necropsy and histopathology examination were performed in all animals in the control group, the test groups and the satellite group in which the extract was discontinued for another 28 days. Body and organ weights, hematological and blood clinical chemistry were also examined. The results suggest that the water extract of Imperata cylindrica (Linn.) Raeusch does not cause acute and subchronic toxicities in rats.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34248326955&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/61414
ISSN: 01253395
Appears in Collections:CMUL: Journal Articles

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