Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/61411
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dc.contributor.authorSiharat Chunlaratthanaphornen_US
dc.contributor.authorNirush Lertprasertsukeen_US
dc.contributor.authorUmarat Srisawaten_US
dc.contributor.authorAmornnat Thuppiaen_US
dc.contributor.authorAnongnad Ngamjariyawaten_US
dc.contributor.authorNadthaganya Suwanlikhiden_US
dc.contributor.authorKanjana Jaijoyen_US
dc.date.accessioned2018-09-10T04:11:37Z-
dc.date.available2018-09-10T04:11:37Z-
dc.date.issued2007-03-01en_US
dc.identifier.issn01253395en_US
dc.identifier.other2-s2.0-34248382578en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34248382578&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/61411-
dc.description.abstractThe study was carried out to evaluate acute and subchronic toxicities of the water extract from the dried fruits of Piper nigrum L. A single oral administration of the extract at a dose of 5,000 mg/kg body weight (5 male, 5 female) did not produce signs of toxicity, behavioral changes, mortality, changes on gross appearance or histopathological changes of internal organs. The subchronic toxicity was determined by oral feeding both male and female rats (10 male, 10 female) daily with the test substance at the doses of 300, 600 and 1,200 mg/kg body weight continuously for 90 days. The examinations of signs, animal behavior and health monitoring showed no abnormalities in the test groups as compared to the controls. The test and control groups (on the 90th day) and the satellite group (on the 118th day) were analyzed by measuring their final body and organ weights, taking necropsy, and examining hematology, blood clinical chemistry and histopathology. The results suggest that the water extract from the dried fruits of P. nigrum does not cause acute or subchronic toxicities in either male or female rats.en_US
dc.subjectMultidisciplinaryen_US
dc.titleAcute and subchronic toxicity study of the water extract from dried fruits of Piper nigrum L. in ratsen_US
dc.typeJournalen_US
article.title.sourcetitleSongklanakarin Journal of Science and Technologyen_US
article.volume29en_US
article.stream.affiliationsDepartment of Preclinical Scienceen_US
article.stream.affiliationsFaculty of Medicine, Thammasat Universityen_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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