Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/61354
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTeraporn Vutyavanichen_US
dc.contributor.authorWaraporn Piromlertamornen_US
dc.contributor.authorWasna Sirirungsien_US
dc.contributor.authorSupachai Sirisukkasemen_US
dc.date.accessioned2018-09-10T04:09:09Z-
dc.date.available2018-09-10T04:09:09Z-
dc.date.issued2007-01-01en_US
dc.identifier.issn17457262en_US
dc.identifier.issn1008682Xen_US
dc.identifier.other2-s2.0-33845987078en_US
dc.identifier.other10.1111/j.1745-7262.2007.00239.xen_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33845987078&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/61354-
dc.description.abstractAim: To investigate the possible causes of oligozoospermia and azoospermia in infertile Thai men, and to find the frequencies of Y chromosome microdeletions and cytogenetic abnormalities in this group. Methods: From June 2003 to November 2005, 50 azoospermic and 80 oligozoospermic men were enrolled in the study. A detailed history was taken for each man, followed by general and genital examinations. Y chromosome microdeletions were detected by multiplex polymerase chain reaction (PCR) using 11 gene-specific primers that covered all three regions of the azoospermic factor (AZFa, AZFb and AZFc). Fifty men with normal semen analysis were also studied. Karyotyping was done with the standard G- and Q-banding. Serum concentrations of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL) and testosterone were measured by electrochemiluminescence immunoassays (ECLIA). Results: Azoospermia and oligozoospermia could be explained by previous orchitis in 22.3%, former bilateral cryptorchidism in 19.2%, abnormal karyotypes in 4.6% and Y chromosome microdeletions in 3.8% of the subjects. The most frequent deletions were in the AZFc region (50%), followed by AZFb (33%) and AZFbc (17%). No significant difference was detected in hormonal profiles of infertile men, with or without microdeletions. Conclusion: The frequencies of Y chromosome microdeletions and cytogenetic abnormalities in oligozoospermic and azoospermic Thai men are comparable with similarly infertile men from other Asian and Western countries. © 2007 Asian Journal of Andrology. Shanghai Institute of Materia Medica, Chinese Academy of Sciences.en_US
dc.subjectMedicineen_US
dc.titleFrequency of Y chromosome microdeletions and chromosomal abnormalities in infertile Thai men with oligozoospermia and azoospermiaen_US
dc.typeJournalen_US
article.title.sourcetitleAsian Journal of Andrologyen_US
article.volume9en_US
article.stream.affiliationsFaculty of Medicine, Thammasat Universityen_US
article.stream.affiliationsChiang Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.