Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/60216
Title: Susceptibilities to antimicrobials and disinfectants in Salmonella isolates obtained from poultry and swine in Thailand
Authors: Rungtip Chuanchuen
Pornpen Pathanasophon
Sirintip Khemtong
Wechsiri Wannaprasat
Pawin Padungtod
Keywords: Business, Management and Accounting
Veterinary
Issue Date: 1-Jun-2008
Abstract: Salmonella enterica isolates from poultry (n=125) and swine (n=132) in Thailand were investigated for antibiotic resistance, susceptibility to disinfectants (benzalkonium chloride (BKC), chlorhexidine digluconate (CHX), zinc chloride and copper sulfate) and cyclohexane tolerance. Forty-two percent were of multiple resistance to antibiotics. The minimum inhibitory concentrations (MICs) of all antibiotics against isolates from swine were higher than that against the isolates from poultry. There were generally few variations in MICs to all disinfectants, indicating that the isolates had either no or only a limited degree of developed resistance to the disinfectants tested. Only 5 isolates (1.9%) were tolerant to cyclohexane. The proton-dependent efflux systems did not play a major role in the reduced susceptibility to BKC and CHX, since susceptibility was not restored when an efflux inhibitor, carbonyl cyanide m-chlorophenylhydrazone (CCCP) was present. Successive exposure to subinhibitory concentrations of BKC and CHX generated mutants resistant to BKC and CHX. A spontaneous BKC-resistant derivative expressed cross-resistance to antibiotics, chloramphenicol and erythromycin. The mechanism responsible for cross-resistance between BKC and antibiotics was not driven by the proton motif force (PMF).
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=47549100895&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60216
ISSN: 13477439
09167250
Appears in Collections:CMUL: Journal Articles

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