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dc.contributor.authorWilliam J. Tayloren_US
dc.contributor.authorH. R. Schumacheren_US
dc.contributor.authorH. S.B. Barafen_US
dc.contributor.authorP. Chapmanen_US
dc.contributor.authorL. Stampen_US
dc.contributor.authorM. Dohertyen_US
dc.contributor.authorF. McQueenen_US
dc.contributor.authorN. Dalbethen_US
dc.contributor.authorN. Schlesingeren_US
dc.contributor.authorD. E. Fursten_US
dc.contributor.authorJ. Vazquez Melladoen_US
dc.contributor.authorM. A. Beckeren_US
dc.contributor.authorA. Kavanaughen_US
dc.contributor.authorW. Louthrenooen_US
dc.contributor.authorT. Bardinen_US
dc.contributor.authorD. Khannaen_US
dc.contributor.authorL. S. Simonen_US
dc.contributor.authorH. Yamanakaen_US
dc.contributor.authorH. K. Choien_US
dc.contributor.authorX. Zengen_US
dc.contributor.authorV. Stranden_US
dc.contributor.authorR. Graingeren_US
dc.contributor.authorD. Cleggen_US
dc.contributor.authorJ. A. Singhen_US
dc.contributor.authorC. Diaz-Torneen_US
dc.contributor.authorM. Boersen_US
dc.contributor.authorP. Gowen_US
dc.contributor.authorV. G. Barskovaen_US
dc.description.abstractObjectives: To reach consensus with recommendations made by an OMERACT Special Interest Group (SIG). Methods: Rheumatologists and industry representatives interested in gout rated and clarified, in three iterations, the importance of domains proposed by the OMERACT SIG for use in acute and chronic gout intervention studies. Consensus was defined as a value of less than 1 of the UCLA/RAND disagreement index. Results: There were 33 respondents (61% response rate); all agreed the initial items were necessary, except "total body urate pool". Additional domains were suggested and clarification sought for defining "joint inflammation" and "musculoskeletal function". Items that demonstrated no clear decision were re-rated in the final iteration. There were six highly rated items (rating 1-2) with four slightly lower rating items (rating 3) for acute gout; and 11 highly rated items with eight slightly lower ratings for chronic gout. Conclusions: Consensus is that the following domains be considered mandatory for acute gout studies: pain, joint swelling, joint tenderness, patient global, physician global, functional disability; and for chronic gout studies: serum urate, gout flares, tophus regression, health-related quality of life, functional disability, pain, patient global, physician global, work disability and joint inflammation. Several additional domains were considered discretionary.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleA modified Delphi exercise to determine the extent of consensus with OMERACT outcome domains for studies of acute and chronic gouten_US
article.title.sourcetitleAnnals of the Rheumatic Diseasesen_US
article.volume67en_US of Otagoen_US of Pennsylvaniaen_US Washington Universityen_US District Health Boarden_US of Nottinghamen_US of Aucklanden_US Robert Wood Johnson Medical School at New Brunswicken_US of California, Los Angelesen_US General de Mexicoen_US of Chicagoen_US of California, San Diegoen_US Mai Universityen_US Paris 7- Denis Dideroten_US Medical Schoolen_US Women's Medical Universityen_US University of British Columbiaen_US Union Medical Collegeen_US University School of Medicineen_US of Utahen_US of Minnesota Twin Citiesen_US de La Santa Creu I Sant Pauen_US University Medical Centeren_US Manukau District Health Boarden_US Nasonova Research Institute of Rheumatologyen_US
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