Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPintusorn Hansakulen_US
dc.contributor.authorChatri Ngamkitidechakulen_US
dc.contributor.authorKornkanok Ingkaninanen_US
dc.contributor.authorWatcharin Panuntoen_US
dc.description.abstractIn vitro study of antiproliferation and cytotoxicity of the hexane and butanolic extracts of the three grass species, namely Leersia hexandra (L.) Sw. ("Yaa sai"), Panicum repens Linn. ("Yaa channakaat"), and Brachiaria mutica (Forsk.) Stapf ("Yaa khon") demonstrated selective antiproliferative properties in both human lung cancer A549 and cervical cancer HeLa cell lines relative to normal human lung fibroblasts MRC-5, with significant differences in IC50 values (p<0.05). The butanolic extract of P. repens Linn. displayed the strongest growth inhibition in A549 and HeLa cells (IC50 2 and 1.1 mg/ml, respectively), whereas all other extracts exhibited only moderate to low antiproliferative effects (IC50 values, 90-980 mg/ml). Most grass extracts induced cell lethality at higher concentrations, suggesting their cytotoxic effects. The ELISA-based apoptosis assay showed that the hexane extract of these grasses triggered a significant increase in the level of apoptosis (p<0.05) in treated A549 cells. However, all the extracts induced ladder-like DNA fragmentation in both tumor cell lines in a dose- and time-dependent manner, suggesting that these extracts exhibit cytotoxicity through apoptotic induction. The study of anti-invasive effects of the three grass species revealed that the hexane extract of L. hexandra (L.) Sw. (50-100 μg/ml) and butanolic extract of P. repens Linn. (1 μg/ml) effectively reduced the invasive capacity of MDA-MB-231 cells.en_US
dc.titleAntiproliferative, apoptotic induction, and antiinvasive effects of Leersia hexandra (L.) Sw., Panicum repens Linn., and Brachiaria mutica (Forsk.) Stapf extracts on human cancer cellsen_US
article.title.sourcetitleSongklanakarin Journal of Science and Technologyen_US
article.volume31en_US of Medicine, Thammasat Universityen_US Mai Universityen_US Universityen_US
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.

Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.