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Title: Early postpartum pharmacokinetics of lopinavir initiated intrapartum in Thai women
Authors: Tim R. Cressey
Russell Van Dyke
Gonzague Jourdain
Thanyawee Puthanakit
Anuvat Roongpisuthipong
Jullapong Achalapong
Prapap Yuthavisuthi
Sinart Prommas
Nantasak Chotivanich
Robert Maupin
Elizabeth Smith
David E. Shapiro
Mark Mirochnick
Keywords: Medicine
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-May-2009
Abstract: Lopinavir (LPV) exposure is reduced during the third trimester of pregnancy. We report the pharmacokinetics of standard LPV-ritonavir dosing (400/100 mg twice daily) in the immediate and early postpartum period when initiated during labor. In 16 human immunodeficiency virus-infected Thai women, the median (range) LPV area under the concentration-time curve and maximum and minimum concentrations in plasma were 99.7 (66.1 to 180.5) μg·h/ml, 11.2 (8.0 to 17.5) μg/ml, and 4.6 (1.7 to 12.5) μg/ml, respectively, at 41 (12 to 74) h after delivery. All of the women attained adequate LPV levels through 30 days postpartum. No serious adverse events were reported. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
ISSN: 10986596
Appears in Collections:CMUL: Journal Articles

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