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dc.contributor.authorPiangkwan Sa-nguanmooen_US
dc.contributor.authorPongpan Tanajaken_US
dc.contributor.authorSasiwan Kerdphooen_US
dc.contributor.authorThidarat Jaiwongkamen_US
dc.contributor.authorXiaojie Wangen_US
dc.contributor.authorGuang Liangen_US
dc.contributor.authorXiaokun Lien_US
dc.contributor.authorChao Jiangen_US
dc.contributor.authorWasana Pratchayasakulen_US
dc.contributor.authorNipon Chattipakornen_US
dc.contributor.authorSiriporn C. Chattipakornen_US
dc.description.abstract© 2017 Elsevier Masson SAS The beneficial effects of Fibroblast Growth Factor 21 (FGF21) on metabolic function and neuroprotection have been shown in earlier research. We have previously shown that the Dipeptidyl Peptidase 4 inhibitor, vildagliptin, also led to improved insulin sensitivity and brain function in the obese-insulin resistant condition. However, the comparative efficacy on the improvement of metabolic function and neuroprotection between FGF21 and vildagliptin in the obese-insulin resistant condition has never been investigated. Twenty-four male Wistar rats were divided into two groups, and received either a normal diet (ND, n = 6) or a high fat diet (HFD, n = 18) for 16 weeks. At week 13, the HFD-fed rats were divided into three subgroups (n = 6/subgroup) to receive either a vehicle, recombinant human FGF21 (0.1 mg/kg/day) or vildagliptin (3 mg/kg/day), for four weeks. ND-fed rats were given a vehicle for four weeks. The metabolic parameters and brain function were subsequently investigated. The results demonstrated that the rats fed on HFD had obese-insulin resistance, increased systemic inflammation, brain mitochondrial dysfunction, increased brain apoptosis, impaired hippocampal plasticity, and demonstrated cognitive decline. FGF21 and vildagliptin effectively attenuated peripheral insulin resistance, brain mitochondrial dysfunction, brain apoptosis and cognitive decline. However, only FGF21 treatment led to significantly reduced body weight gain, visceral fat, systemic inflammation, improved hippocampal synaptic plasticity, enhanced FGF21 mediated signaling in the brain leading to prevention of early cognitive decline. These findings suggest that FGF21 exerts greater efficacy than vildagliptin in restoring metabolic function as well as brain function in cases of obese-insulin resistant rats.en_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleFGF21 and DPP-4 inhibitor equally prevents cognitive decline in obese ratsen_US
article.title.sourcetitleBiomedicine and Pharmacotherapyen_US
article.volume97en_US Mai Universityen_US Medical Universityen_US
Appears in Collections:CMUL: Journal Articles

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