Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/58895
Title: Diagnosis and treatment of cardiac iron overload in transfusion-dependent thalassemia patients
Authors: Natthaphat Siri-Angkul
Siriporn C. Chattipakorn
Nipon Chattipakorn
Keywords: Medicine
Issue Date: 3-Jun-2018
Abstract: © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Thalassemia is among the most common genetic diseases. Patients with severe forms of the disease are transfusion-dependent, leading to iron overload. A condition which can eventually develop in the iron-loaded heart is iron overload cardiomyopathy, a debilitating disease that accounts for the majority of deaths in thalassemia patients. Areas covered: This review article provides a comprehensive summary of the diagnosis and treatment of cardiac iron overload in transfusion-dependent thalassemia patients, with discussion covering current weak points and potential improvements of the relevant diagnostic and therapeutic strategies. Expert commentary: Current limitations of various diagnostic techniques for iron overload cardiomyopathy include suboptimal accuracy, untimely detection, or inadequate accessibility, and novel modalities are required to overcome these shortcomings. Treatment should address key pathophysiologic mechanisms of iron overload cardiomyopathy, which include cardiac iron mishandling and iron-induced oxidative injury. Apart from the promotion of iron removal by chelators, prevention of cardiac iron deposition and attenuation of oxidative damage should also be rigorously investigated on a cell-to-bedside basis.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048374401&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/58895
ISSN: 17474094
17474086
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.