Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/58842
Title: Strong impact of ethnicity on effectiveness of the first trimester maternal serum screen of fetal Down syndrome
Authors: Thitikarn Lerthiranwong
Chanane Wanapirak
Supatra Sirichotiyakul
Fuanglada Tongprasert
Kasemsri Srisupundit
Suchaya Luewan
Theera Tongsong
Keywords: Medicine
Issue Date: 2-Nov-2018
Abstract: © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group. Objectives: The objective of this study is to compare the effectiveness of first-trimester maternal serum screening (MSS) for fetal Down syndrome among Thai women between the method using Caucasian reference ranges with racial factor correction (CRR-RC) and that using Thai reference ranges (TRR). Methods: A prospective database of MSS was accessed. The levels of PAPP-A and beta-hCG were calculated to determine their MoMs (multiple of medians) by two methods: (1) CRR-RC for Asian women and (2) TRR. The MoMs from both methods were used to determine the fetal risk. Results: Of 24,885 women including 36 fetuses with Down syndrome, the detection rates were significantly higher with TRR when compared with CRR-RC, 77.8 and 63.9%, respectively, p <.001. Additionally, the false-positive rates were significantly lower with TRR when compared to CRR-RC (7.5 versus 12.5%, respectively, p <.001) Conclusions: The effectiveness of MSS was much better by using our own reference ranges rather than the method of racial factor correction. The important insight is that ethnicity strongly impacts on the effectiveness that cannot be completely corrected by ethnic factor. MSS derived by the CRR-RC in other regions should be interpreted with high precaution, especially where the biophysical characteristics of the women are much different from Caucasian population.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026734601&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/58842
ISSN: 14764954
14767058
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.