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dc.contributor.authorAnorut Jenwitheesuken_US
dc.contributor.authorSeongjoon Parken_US
dc.contributor.authorPrapimpun Wongchitraten_US
dc.contributor.authorJiraporn Tocharusen_US
dc.contributor.authorSujira Mukdaen_US
dc.contributor.authorIsao Shimokawaen_US
dc.contributor.authorPiyarat Govitrapongen_US
dc.date.accessioned2018-09-05T04:22:51Z-
dc.date.available2018-09-05T04:22:51Z-
dc.date.issued2018-01-01en_US
dc.identifier.issn15736903en_US
dc.identifier.issn03643190en_US
dc.identifier.other2-s2.0-85026772603en_US
dc.identifier.other10.1007/s11064-017-2369-7en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026772603&origin=inwarden_US
dc.identifier.urihttp://cmuir.cmu.ac.th/jspui/handle/6653943832/58339-
dc.description.abstract© 2017, Springer Science+Business Media, LLC. It has been suggested that age-related neurodegeneration might be associated with neuropeptide Y (NPY); sirtuin1 (SIRT1) and forkhead box transcription factors O subfamily (FOXOs) pathways. Melatonin, a hormone mainly secreted by the pineal gland, is another anti-aging agent associated with the SIRT1-FOXOs pathway. This study aimed to compare the effects of melatonin (Mel) and caloric restriction (CR) on the expression of Sirt1, FoxO1, FoxO3a and FOXOs target genes in the aging mouse hippocampus. Neuropeptide Y-knockout (NpyKO) and wild-type (WT) male mice aged 19 months were previously treated either with food ad libitum or CR for 16 months. WT old animals were divided into four groups: control, CR, Mel and CR+Mel treated groups. The Mel and CR+Mel were treated with melatonin 10 mg/kg, daily, subcutaneously for 7 consecutive days. Mel treatment upregulated the mRNA expression of Sirt1, FOXOs (FoxO1 and FoxO3a) target genes that regulated the cell cycle [e.g., cyclin-dependent kinase inhibitor 1B (p27)], Wingless and INT-1 (Wnt1) and inducible signaling pathway protein 1 (Wisp1) in the aged mouse hippocampus. CR treatment also showed the similar actions. However, the mRNA expression of Sirt1, FoxO1, FoxO3a, p27 or Wisp1 did not alter in the CR+Mel group when compared with CR or Mel group. Melatonin could not produce any additive effect on the CR treatment group, suggesting that both treatments mimicked the effect, possibly via the same pathway. NPY which mediates physiological adaptations to energy deficits is an essential link between CR and longevity in mice. In order to focus on the role of Npy in mediating the effects of melatonin, the gene expression between NpyKO and WT male mice were compared. Our data showed that, in the absence of Npy, melatonin could not mediate effects on those gene expressions, suggesting that Npy was required for melatonin to mediate the effect, possibly, on life extension.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectNeuroscienceen_US
dc.titleComparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathwayen_US
dc.typeJournalen_US
article.title.sourcetitleNeurochemical Researchen_US
article.volume43en_US
article.stream.affiliationsMahidol Universityen_US
article.stream.affiliationsNagasaki University School of Medicineen_US
article.stream.affiliationsChiang Mai Universityen_US
article.stream.affiliationsChulabhorn Royal Academyen_US
Appears in Collections:CMUL: Journal Articles

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