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Title: The efficacy of colchicine and dapsone combination therapy in relapsed immune thrombocytopenia
Authors: Thanawat Rattanathammethee
Wasan Theerajangkhaphichai
Ekarat Rattarittamrong
Sasinee Hantrakool
Chatree Chai-Adisaksopha
Lalita Norasetthada
Adisak Tantiworawit
Keywords: Medicine
Issue Date: 23-Feb-2017
Abstract: © T. Rattanathammethee et al., 2017. The aim of the present paper is to evaluate the efficacy and safety of colchicine and dapsone combination therapy in cases of steroid-dependent, relapsed and refractory immune thrombocytopenia (ITP). This is a retrospective study of ITP patients who attended the Hematology Clinic at Chiang Mai University Hospital (Thailand) from 1 January 2008 to 30 September 2014. Medical records and clinical data were reviewed for efficacy and adverse effects. Sixty-four ITP patients received the combination therapy. The median age was 46 years and 70.3% were female. The majority (65.6%) were relapsed ITP patients. Median platelet count before starting treatment was 22.6×109/L. The response rate was 82.8%, with 75.0% of patients having a complete response. Median time to response was 8 weeks. The response rate was higher in relapsed patients (90.4%) compared to refractory (61.5%) and steroid-dependent patients (77.8%). Steroid treatment was discontinued in 30 patients (50%) following combination therapy. The most common side effect was hemolysis due to dapsone which was found in eight patients (12.5%). We can therefore conclude that combination therapy with colchicine and dapsone is an alternative second-line therapy option in relapsed ITP cases with acceptable side effects.
ISSN: 20388330
Appears in Collections:CMUL: Journal Articles

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