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Title: Ph<inf>3</inf>P/I<inf>2</inf>-mediated synthesis of N,N′,N″-substituted guanidines and 2-iminoimidazolin-4-ones from aryl isothiocyanates
Authors: Sirilak Wangngae
Mookda Pattarawarapan
Wong Phakhodee
Keywords: Chemistry
Issue Date: 1-Jan-2017
Abstract: © 2017 American Chemical Society. A convenient one-pot procedure for the synthesis of acyclic and cyclic guanidines mediated by the Ph3P/I2system is described. Sequential condensation of aryl isothiocyanates with amines followed by dehydrosulfurization and guanylation could lead to both symmetric and unsymmetric N,N′,N″-substituted derivatives. Through a tandem guanylation-cyclization, a series of 2-iminoimidazolin-4-ones could also be prepared in good yields from the reaction of aryl isothiocyanates with amino acid methyl esters.
ISSN: 15206904
Appears in Collections:CMUL: Journal Articles

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