Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPensak Jantrawuten_US
dc.contributor.authorTanpong Chaiwariten_US
dc.contributor.authorKittisak Jantanasakulwongen_US
dc.contributor.authorClaire Hélène Brachaisen_US
dc.contributor.authorOdile Chambinen_US
dc.description.abstract© 2017 by the authors. This study developed the interests of low-methoxyl pectin (LMP) together with plasticizers for the preparation of elastic thin films. The effect of different plasticizer types (glycerol: Gly; sorbitol: Sor propylene glycol: PG; and polyethylene glycol 300: PEG 300) and concentrations (20-40% w/w) on mechanical and thermal properties of LMP films as well as on in vitro release of indomethacin were evaluated. Without any plasticizer, a brittle LMP film with low tensile strength and % elongation at break was obtained. Addition of plasticizers from 20% to 40% caused reduction in the tensile strength and Young's modulus values, whereas percent elongation was increased. Forty percent Gly-plasticized and PG-plasticized films were selected to deliver indomethacin in comparison with non-plasticized film. No significant difference in indomethacin release profiles was displayed between the films. The analysis of indomethacin release model indicated that more than one drug release mechanism from the film formulation was involved and possibly the combination of both diffusion and erosion. Even though indomethacin incorporated in non-plasticized film showed similar release profile, Gly or PG should be added to enhanced film flexibility and decrease film brittleness.en_US
dc.subjectMaterials Scienceen_US
dc.titleEffect of plasticizer type on tensile property and in vitro indomethacin release of thin films based on low-methoxyl pectinen_US
article.volume9en_US Mai Universityen_US Bourgogne Franche-Comteen_US de Bourgogneen_US
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.

Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.