Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/56972
Title: Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf>
Authors: Wong Phakhodee
Sirilak Wangngae
Mookda Pattarawarapan
Keywords: Chemistry
Issue Date: 4-Aug-2017
Abstract: © 2017 American Chemical Society. Readily available N-substituted amides or their requisite carboxylic acids or acid chlorides have been used to construct 2,3-disubstituted-3H-quinazolin-4-ones in a one-pot procedure. Key transformation in this convergent approach involves Ph3P-I2-mediated formation of amidine upon condensation of an amide or the intermediate amide with methyl anthranilate. Cyclization of the amidine-tethered anthranilate then affords 2,3-disubstituted-3H-quinazolin-4-ones in good to excellent yields under mild conditions.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85027057783&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/56972
ISSN: 15206904
00223263
Appears in Collections:CMUL: Journal Articles

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