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dc.contributor.authorSirada Boonyaketgosonen_US
dc.contributor.authorVatcharin Rukachaisirikulen_US
dc.contributor.authorSouwalak Phongpaichiten_US
dc.contributor.authorKongkiat Trisuwanen_US
dc.description.abstract© 2017 Elsevier Ltd Four new natural products, including three arylbenzofurans named heterophyllenes A-C (1–3), and one stilbene named heterophyllene D (4), together with twenty-one known compounds were isolated from the twigs of Artocarpus heterophyllus and their structures elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopy. The cytotoxic activity of selected compounds against KB, MCF-7 and NCI-H187 cell lines was evaluated. Heterophyllene C (3) exhibited cytotoxicity against the MCF-7 cell line with an IC50value of 12.56 μM. Additionally, the known compounds norartocarpin and artocarpin showed cytotoxic activity against MCF-7 and KB cell lines with IC50values of 10.04 and 13.57 μM, respectively. Both compounds also displayed cytotoxicity against the NCI-H187 cell line with values of 14.78 and 14.21 μM, respectively.en_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleCytotoxic arylbenzofuran and stilbene derivatives from the twigs of Artocarpus heterophyllusen_US
article.title.sourcetitleTetrahedron Lettersen_US
article.volume58en_US Mai Universityen_US of Songkla Universityen_US
Appears in Collections:CMUL: Journal Articles

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