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DC Field | Value | Language |
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dc.contributor.author | Sakorn Pornprasert | en_US |
dc.contributor.author | Choosak Thongsat | en_US |
dc.contributor.author | Uraiporn Panyachadporn | en_US |
dc.date.accessioned | 2018-09-05T03:30:13Z | - |
dc.date.available | 2018-09-05T03:30:13Z | - |
dc.date.issued | 2017-03-04 | en_US |
dc.identifier.issn | 1532432X | en_US |
dc.identifier.issn | 03630269 | en_US |
dc.identifier.other | 2-s2.0-85020670119 | en_US |
dc.identifier.other | 10.1080/03630269.2017.1323763 | en_US |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85020670119&origin=inward | en_US |
dc.identifier.uri | http://cmuir.cmu.ac.th/jspui/handle/6653943832/56785 | - |
dc.description.abstract | © 2017 Informa UK Limited, trading as Taylor & Francis Group. Red cell indexes and formulas have been established as simple, fast, and inexpensive tools to differentiate β-thalassemia (β-thal) trait from iron deficiency anemia. However, none of them showed 100.0% sensitivity and specificity. Moreover, one index may show greater sensitivity and specificity in one population but is ineffective in another population. This study evaluated the diagnostic reliability of a combination of two red cell indexes [red blood cell (RBC) and red blood cell distribution width (RDW)] and nine formulas called ‘11T score’ for differentiation of β-thal trait and iron deficiency anemia in the Thai population. A total of 103 cases, 67 β-thal trait and 36 iron deficiency anemia, Thai subjects with microcytic hypochromic anemia [mean corpuscular volume (MCV) <80.0 fL and mean corpuscular hemoglobin (Hb) (MCH) <27.0 pg] were involved in this retrospective study. The results showed that the 11T score with a cutoff value of 7 was able to discriminate between β-thal trait and iron deficiency anemia with sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and efficiency (EFF) higher than 70.0%. It also had 85.4% of correctly identified cases and the highest value of Youden’s Index (YI) (73.8%) when compared to the 11T score with other cutoff values (5, 6, 8 and 9) and other indexes. Thus, the 11T score with the cutoff value of 7 could be used to differentiate β-thal trait from iron deficiency anemia in the Thai population. | en_US |
dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
dc.subject | Medicine | en_US |
dc.title | Evaluation of Applying a Combination of Red Cell Indexes and Formulas to Differentiate β-Thalassemia Trait from Iron Deficiency Anemia in the Thai Population | en_US |
dc.type | Journal | en_US |
article.title.sourcetitle | Hemoglobin | en_US |
article.volume | 41 | en_US |
article.stream.affiliations | Chiang Mai University | en_US |
Appears in Collections: | CMUL: Journal Articles |
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