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Title: A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans
Authors: Tadayoshi Onozawa
Mariko Kitajima
Noriyuki Kogure
Nichakan Peerakam
Dammrong Santiarworn
Hiromitsu Takayama
Keywords: Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 28-Jul-2017
Abstract: © 2017 The American Chemical Society and American Society of Pharmacognosy. A new cyclopeptide, ophiorrhisine A (1), a new tetrahydroisoquinoline alkaloid, 7′,10-dide-O-methylcephaeline (2), two known β-carboline alkaloids, and four known tetrahydroisoquinoline alkaloids were isolated from Ophiorrhiza nutans (Rubiaceae). Compound 1 is a tetrapeptide possessing a 14-membered paracyclophane ring and a novel N,N,N-trimethyltyrosine residue in the side chain. The stereochemistry at the aryl-alkyl ether bond was different from that of other known 14-membered paracyclophanes. The structure of 2 was established by spectroscopic analysis and semisynthesis.
ISSN: 15206025
Appears in Collections:CMUL: Journal Articles

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