Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/56665
Title: Al-Awadi-Raas-Rothschild syndrome with dental anomalies and a novel WNT7A mutation
Authors: Piranit Nik Kantaputra
Seema Kapoor
Prashant Verma
Massupa Kaewgahya
Katsushige Kawasaki
Atsushi Ohazama
James R. Ketudat Cairns
Keywords: Biochemistry, Genetics and Molecular Biology
Medicine
Issue Date: 1-Dec-2017
Abstract: © 2017 Elsevier Masson SAS Al-Awadi-Raas-Rothschild syndrome (AARRS; OMIM 276820) is a very rare autosomal recessive limb malformation syndrome caused by WNT7A mutations. AARRS is characterized by various degrees of limb aplasia and hypoplasia. Normal intelligence and malformations of urogenital system are frequent findings. Complete loss of WNT7A function has been shown to cause AARRS, however, its partial loss leads to the milder malformation, Fuhrmann syndrome. An Indian boy affected with AARRS is reported. A novel homozygous base substitution mutation c.550A > C (p.Asn184Asp) is identified in the patient. Parents were heterozygous for the mutation. In addition to the typical features of AARRS, the patient had agenesis of the mandibular left deciduous lateral incisor. The heterozygous parents had microdontia of the maxillary left permanent third molar and taurodontism (enlarged dental pulp chamber at the expense of root) in a number of their permanent molars. Whole exome sequencing of the patient and his parents ruled out mutations in 11 known hypodontia-associated genes including WNT10A, MSX1, EDA, EDAR, EDARADD, PAX9, AXIN2, GREM2, NEMO, KRT17, and TFAP2B. In situ hybridization during tooth development showed Wnt7a expression in wild-type tooth epithelium at E14.5. All lines of evidence suggest that WNT7A has important role in tooth development and its mutation may lead to tooth agenesis, microdontia, and taurodontism. Oral examination of patients with AARRS and Fuhrmann syndromes is highly recommended.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029545835&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/56665
ISSN: 18780849
17697212
Appears in Collections:CMUL: Journal Articles

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