Please use this identifier to cite or link to this item:
Title: The effect of different progestogens on sleep in postmenopausal women: a randomized trial
Authors: Ekachai Leeangkoonsathian
Tawiwan Pantasri
Somsak Chaovisitseree
Nuntana Morakot
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 2-Dec-2017
Abstract: © 2017 Informa UK Limited, trading as Taylor & Francis Group. Background: While progesterone affects sleep, different types of it might affect sleep differently. Methods: One hundred Thai women, who complained of insomnia, visited the Menopause Clinic at Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Thailand from February 2014 to March 2015, and were divided randomly into two groups. Both groups received daily hormonal treatment that included estradiol valerate (progynova) at 1 mg. The first group also received dydrogesterone (duphaston®) at 10 mg and the second group micronized progesterone (utrogestran®) at 100 mg. The clinical symptoms and Pittsburgh Sleep Quality Index (PSQI) were recorded for three consecutive months after treatment. This study was registered with (code number NCT02086032). Results: Sleep quality improved in both groups (10.52 ± 4.27 to 4.91 ± 3.15 in the dydrogesterone group and 10.16 ± 3.60 to 6.27 ± 3.04 in the micronized progesterone group, p value 0.08). Women in the micronized progesterone group had fewer overall side effects than those in the dydrogesterone group. Conclusion: Sleep quality of peri-postmenopausal women with insomnia improved dramatically after the first month of hormonal treatment. However, more participating patients are necessary to ascertain the differences in sleep quality from dydrogesterone and micronized progesterone treatment.
ISSN: 14730766
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.

Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.