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Title: Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa
Authors: Isaraporn Polbuppha
Wisanu Maneerat
Tawanun Sripisut
Thunwadee Limtharakul
Sarot Cheenpracha
Stephen G. Pyne
Chatchai Muanprasat
Sawinee Seemakhan
Suparerk Borwornpinyo
Surat Laphookhieo
Keywords: Agricultural and Biological Sciences
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2017
Abstract: The first phytochemical investigation of the twig extracts of Maclura fruticosa led to the isolation and identification of a new xanthone, maclurafruticosone (1), together with 14 known compounds (2-15). All compounds were elucidated using spectroscopic methods as well as through comparisons made with data reported in the literature. Some isolated compounds were evaluated for their antioxidant, α-glucosidase inhibitory and cytotoxic activities. Compound 4, 6 and 7 showed significant antioxidant activity against DPPH radicals with IC50values ranging from 7.45-V16.12 μM. Compound 4 also exhibited potent activity against ABTS.,h+scavenging activity with an IC50value of 0.55 iÓ 0.01 £gM which was better than positive control (ascorbic acid, IC502.35-0.17 μM). Compound 12 showed significant α-glucosidase inhibitory activity with an IC50value of 0.02-0.37 mM. Compounds 5, 6 and 12 showed weak cytotoxic activities against a colon cancer cell line with IC50values ranging from 22.35-47.62 μM.
ISSN: 15559475
Appears in Collections:CMUL: Journal Articles

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