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|Title:||Analysis of complete genome sequences of G9P rotavirus strains from human and piglet with diarrhea provides evidence for whole-genome interspecies transmission of nonreassorted porcine rotavirus|
|Keywords:||Agricultural and Biological Sciences|
Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
|Abstract:||© 2016 Whole genomes of G9P human (RVA/Human-wt/THA/CMH-S070-13/2013/G9P) and porcine (RVA/Pig-wt/THA/CMP-015-12/2012/G9P) rotaviruses concurrently detected in the same geographical area in northern Thailand were sequenced and analyzed for their genetic relationships using bioinformatic tools. The complete genome sequence of human rotavirus RVA/Human-wt/THA/CMH-S070-13/2013/G9P was most closely related to those of porcine rotavirus RVA/Pig-wt/THA/CMP-015-12/2012/G9P and to those of porcine-like human and porcine rotaviruses reference strains than to those of human rotavirus reference strains. The genotype constellation of G9P detected in human and piglet were identical and displayed as the G9-P-I5-R1-C1-M1-A8-N1-T1-E1-H1 genotypes with the nucleotide sequence identities of VP7, VP4, VP6, VP1, VP2, VP3, NSP1, NSP2, NSP3, NSP4, and NSP5 at 99.0%, 99.5%, 93.2%, 97.7%, 97.7%, 85.6%, 89.5%, 93.2%, 92.9%, 94.0%, and 98.1%, respectively. The findings indicate that human rotavirus strain RVA/Human-wt/THA/CMH-S070-13/2013/G9P containing the genome segments of porcine genetic backbone is most likely a human rotavirus of porcine origin. Our data provide an evidence of interspecies transmission and whole-genome transmission of nonreassorted G9P porcine RVA to human occurring in nature in northern Thailand.|
|Appears in Collections:||CMUL: Journal Articles|
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