Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/56594
Title: A new ajmaline-type alkaloid from the roots of rauvolfia serpentina
Authors: Thitima Rukachaisirikul
Suwadee Chokchaisiri
Parichat Suebsakwong
Apichart Suksamrarn
Chainarong Tocharus
Keywords: Agricultural and Biological Sciences
Medicine
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2017
Abstract: A new ajmaline-type alkaloid, 21-O-methylisoajmaline (1), together with twenty-one known compounds, a mixture of β-sitosterol (2) and stigmasterol (3), reserpinine (4), tetrahydroalstonine (5), reserpine (6), venoterpine (7), yohimbine (8), 6′-O-(3,4,5-trimethoxybenzoyl)glomeratose A (9), isoajmaline (10), 3-epi-α-yohimbine (11), methyl 3,4,5-trimethoxy-trans-cinnamate (12), a mixture of β-sitosterol 3-O-β-D-glucopyranoside (13) and stigmasterol 3-O-β-D-glucopyranoside (14), rescidine (15), 7-deoxyloganic acid (16), ajmaline (17), suaveoline (18), (+)-tetraphyllicine (19), loganic acid (20), 3-hydroxysarpagine (21), and sarpagine (22), were isolated from the roots of Rauvolfia serpentina. Their structures were elucidated by spectroscopic data analysis and comparison with literature data. Compounds 11, 12 and 15 were for the first time identified from the genus Rauvolfia and 5, 7, 11, 12, 15, 18 and 22 were found from R. serpentina for the first time. Compound 11 showed moderate anticholinesterase activity with IC50value of 15.58 μM, whereas 6 exhibited strong vasorelaxant activity with the EC50 value of 0.05 μM.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85019697355&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/56594
ISSN: 15559475
1934578X
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.


Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.