Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSarot Cheenprachaen_US
dc.contributor.authorPannakorn Boapunen_US
dc.contributor.authorThunwadee Limtharakul (née Ritthiwigrom)en_US
dc.contributor.authorSurat Laphookhieoen_US
dc.contributor.authorStephen G. Pyneen_US
dc.description.abstract© 2017 Informa UK Limited, trading as Taylor & Francis Group The phytochemical investigation of an alkaloidal extract of Holarrhena pubescens roots led to the isolation and identification of a new pregnene-type alkaloid, mokluangin D (1), together with nine known steroidal alkaloids (2–10). The structure of the new metabolite was determined on the basis of spectroscopic analyses including 1D- and 2D-NMR spectroscopy and mass spectrometry. Compounds 3 and 4 showed potent antimalarial activity against Plasmodium falciparum K1 stain with IC50values of 1.2 and 2.0 μM, respectively, and showed weak cytotoxic activity against the NCI-H187 cell line with IC50values of 27.7 and 30.6 μM, respectively. The substituent groups at C-3 and the carbonyl group at C-18 are important for the activity against the P. falciparum K1 stain.en_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleAntimalarial and cytotoxic activities of pregnene-type steroidal alkaloids from Holarrhena pubescens rootsen_US
article.title.sourcetitleNatural Product Researchen_US of Phayaoen_US Mai Universityen_US Fah Luang Universityen_US of Wollongongen_US
Appears in Collections:CMUL: Journal Articles

Files in This Item:
There are no files associated with this item.

Items in CMUIR are protected by copyright, with all rights reserved, unless otherwise indicated.