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dc.contributor.authorJin Young Ahnen_US
dc.contributor.authorDavid Boettigeren_US
dc.contributor.authorSasisopin Kiertiburanakulen_US
dc.contributor.authorTuti Parwati Meratien_US
dc.contributor.authorBui Vu Huyen_US
dc.contributor.authorWing Wai Wongen_US
dc.contributor.authorRossana Ditangcoen_US
dc.contributor.authorMan Po Leeen_US
dc.contributor.authorShinichi Okaen_US
dc.contributor.authorNicolas Durieren_US
dc.contributor.authorJun Yong Choien_US
dc.contributor.authorC. V. Meanen_US
dc.contributor.authorV. Saphonnen_US
dc.contributor.authorK. Vohithen_US
dc.contributor.authorF. J. Zhangen_US
dc.contributor.authorH. X. Zhaoen_US
dc.contributor.authorN. Hanen_US
dc.contributor.authorM. P. Leeen_US
dc.contributor.authorP. C.K. Lien_US
dc.contributor.authorW. Lamen_US
dc.contributor.authorY. T. Chanen_US
dc.contributor.authorN. Kumarasamyen_US
dc.contributor.authorS. Saghayamen_US
dc.contributor.authorC. Ezhilarasien_US
dc.contributor.authorS. Pujarien_US
dc.contributor.authorK. Joshien_US
dc.contributor.authorS. Gaikwaden_US
dc.contributor.authorA. Chitalikaren_US
dc.contributor.authorD. N. Wirawanen_US
dc.contributor.authorF. Yulianaen_US
dc.contributor.authorE. Yunihastutien_US
dc.contributor.authorD. Imranen_US
dc.contributor.authorA. Widhanien_US
dc.contributor.authorS. Okaen_US
dc.contributor.authorJ. Tanumaen_US
dc.contributor.authorT. Nishijimaen_US
dc.contributor.authorJ. Y. Choien_US
dc.contributor.authorS. Naen_US
dc.contributor.authorJ. M. Kimen_US
dc.contributor.authorB. L.H. Simen_US
dc.contributor.authorY. M. Ganien_US
dc.contributor.authorR. Daviden_US
dc.contributor.authorA. Kamarulzamanen_US
dc.contributor.authorS. F. Syed Omaren_US
dc.contributor.authorS. Ponnampalavanaren_US
dc.contributor.authorI. Azwaen_US
dc.contributor.authorR. Ditangcoen_US
dc.contributor.authorE. Uyen_US
dc.contributor.authorR. Bantiqueen_US
dc.contributor.authorW. W. Wongen_US
dc.contributor.authorW. W. Kuen_US
dc.contributor.authorP. C. Wuen_US
dc.contributor.authorO. T. Ngen_US
dc.contributor.authorP. L. Limen_US
dc.contributor.authorL. S. Leeen_US
dc.contributor.authorP. S. Ohnmaren_US
dc.contributor.authorP. Phanuphaken_US
dc.contributor.authorK. Ruxrungthamen_US
dc.contributor.authorA. Avihingsanonen_US
dc.contributor.authorP. Chusuten_US
dc.contributor.authorS. Sirivichayakulen_US
dc.contributor.authorS. Sungkanuparphen_US
dc.contributor.authorL. Chumlaen_US
dc.contributor.authorN. Sanmeemaen_US
dc.contributor.authorR. Chaiwarithen_US
dc.contributor.authorT. Sirisanthanaen_US
dc.contributor.authorW. Kotarathititumen_US
dc.contributor.authorJ. Praparattanapanen_US
dc.contributor.authorP. Kantipongen_US
dc.contributor.authorP. Kambuaen_US
dc.contributor.authorW. Ratanasuwanen_US
dc.contributor.authorR. Sriondeeen_US
dc.contributor.authorV. K. Nguyenen_US
dc.contributor.authorV. H. Buien_US
dc.contributor.authorT. H.D. Nguyenen_US
dc.contributor.authorT. D. Nguyenen_US
dc.contributor.authorT. T. Phamen_US
dc.contributor.authorD. D. Cuongen_US
dc.contributor.authorH. L. Haen_US
dc.contributor.authorA. H. Sohnen_US
dc.contributor.authorN. Durieren_US
dc.contributor.authorB. Petersenen_US
dc.contributor.authorD. A. Cooperen_US
dc.contributor.authorM. G. Lawen_US
dc.contributor.authorA. Jiamsakulen_US
dc.contributor.authorD. C. Boettigeren_US
dc.description.abstractCopyright © 2016 Ahn JY et al; licensee International AIDS Society. Introduction: Outbreaks of syphilis have been described among HIV-infected men who have sex with men (MSM) in Western communities, whereas reports in Asian countries are limited. We aimed to characterize the incidence and temporal trends of syphilis among HIV-infected MSM compared with HIV-infected non-MSM in Asian countries. Methods: Patients enrolled in the TREAT Asia HIV Observational Database cohort and with a negative non-treponemal test since enrolment were analyzed. Incidence of syphilis seroconversion, defined as a positive non-treponemal test after previously testing negative, was evaluated among patients at sites performing non-treponemal tests at least annually. Factors associated with syphilis seroconversion were investigated at sites doing non-treponemal testing in all new patients and subsequently testing routinely or when patients were suspected of having syphilis. Results: We included 1010 patients from five sites that performed non-treponemal tests in all new patients; those included had negative non-treponemal test results during enrolment and subsequent follow-ups. Among them, 657 patients were from three sites conducting regular non-treponemal testing. The incidence of syphilis seroconversion was 5.38/100 person-years (PY). Incidence was higher in MSM than non-MSM (7.64/100 PY vs. 2.44/100 PY, p<0.001). Among MSM, the incidence rate ratio (IRR) for every additional year from 2009 was 1.19 (p=0.051). MSM status (IRR 3.48, 95% confidence interval (CI) 1.88-6.47), past syphilis diagnosis (IRR 5.15, 95% CI 3.69-7.17) and younger age (IRR 0.84 for every additional 10 years, 95% CI 0.706-0.997) were significantly associated with syphilis seroconversion. Conclusions: We observed a higher incidence of syphilis seroconversion among HIV-infected MSM and a trend to increasing annual incidence. Regular screening for syphilis and targeted interventions to limit transmission are needed in this population.en_US
dc.titleIncidence of syphilis seroconversion among HIV-infected persons in Asia: Results from the TREAT Asia HIV Observational Databaseen_US
article.title.sourcetitleJournal of the International AIDS Societyen_US
article.volume19en_US University College of Medicineen_US Medical Centeren_US of New South Wales (UNSW) Australiaen_US Universityen_US Udayanaen_US Hospital for Tropical Diseasesen_US General Hospital-Taipeien_US Elizabeth Hospital Hong Kongen_US Center for Global Health and Medicineen_US for AIDS Researchen_US Center for HIV/AIDSen_US Medical University Chinaen_US Medical Centre Indiaen_US of Infectious Diseasesen_US of Indonesia, RSUPN Dr. Cipto Mangunkusumoen_US Buloh Hospitalen_US of Malaya Medical Centreen_US Tock Seng Hospitalen_US HIV Netherlands Australia Thailand Research Collaborationen_US Mai Universityen_US Prachanukroh Hospitalen_US Mai Hospitalen_US
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