Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/56218
Title: Involvement of CD147 on multidrug resistance through the regulation of P-glycoprotein expression in K562/ADR leukemic cell line
Authors: Aoranit Somno
Songyot Anuchapreeda
Nuttapol Chruewkamlow
Supansa Pata
Watchara Kasinrerk
Sawitree Chiampanichayakul
Keywords: Medicine
Issue Date: 1-Jan-2016
Abstract: © 2016 The Authors The relationship between P-gp and CD147 in the regulation of MDR in leukemic cells has not been reported. This study aimed to investigate the correlation between CD147 and P-gp in the regulation of drug resistance in the K562/ADR leukemic cell line. The results showed that drug-resistant K562/ADR cells expressed significantly higher P-gp and CD147 levels than drug-free K562/ADR cells. To determine the regulatory effect of CD147 on P-gp expression, anti-CD147 antibody MEM-M6/6 significantly decreased P-gp and CD147 mRNA and protein levels. This is the first report to show that CD147 mediates MDR in leukemia through the regulation of P-gp expression.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84984830212&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/56218
ISSN: 22130489
Appears in Collections:CMUL: Journal Articles

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