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dc.contributor.authorTinakon Wongpakaranen_US
dc.contributor.authorNahathai Wongpakaranen_US
dc.contributor.authorSitthinant Tanchakvaranonten_US
dc.contributor.authorPutipong Bookkamanaen_US
dc.contributor.authorManee Pinyopornpanishen_US
dc.contributor.authorKamonporn Wannariten_US
dc.contributor.authorSirina Satthapisiten_US
dc.contributor.authorDaochompu Nakawiroen_US
dc.contributor.authorThanita Hiranyatheben_US
dc.contributor.authorKulvadee Thongpibulen_US
dc.description.abstract© 2016 Wongpakaran et al. Purpose: Despite the fact that pain is related to depression, few studies have been conducted to investigate the variables that mediate between the two conditions. In this study, the authors explored the following mediators: cognitive function, self-sacrificing interpersonal problems, and perception of stress, and the effects they had on pain symptoms among patients with depressive disorders. Participants and methods: An analysis was performed on the data of 346 participants with unipolar depressive disorders. The 17-item Hamilton Depression Rating Scale, Mini-Mental State Examination, the pain subscale of the health-related quality of life (SF-36), the self-sacrificing subscale of the Inventory of Interpersonal Problems, and the Perceived Stress Scale were used. Parallel multiple mediator and serial multiple mediator models were used. An alternative model regarding the effect of self-sacrificing on pain was also proposed. Results: Perceived stress, self-sacrificing interpersonal style, and cognitive function were found to significantly mediate the relationship between depression and pain, while controlling for demographic variables. The total effect of depression on pain was significant. This model, with an additional three mediators, accounted for 15% of the explained variance in pain compared to 9% without mediators. For the alternative model, after controlling for the mediators, a nonsignificant total direct effect level of self-sacrificing was found, suggesting that the effect of self-sacrificing on pain was based only on an indirect effect and that perceived stress was found to be the strongest mediator. Conclusion: Serial mediation may help us to see how depression and pain are linked and what the fundamental mediators are in the chain. No significant, indirect effect of self-sacrificing on pain was observed, if perceived stress was not part of the depression and/or cognitive function mediational chain. The results shown here have implications for future research, both in terms of testing the model and in clinical application.en_US
dc.titleDepression and pain: Testing of serial multiple mediatorsen_US
article.title.sourcetitleNeuropsychiatric Disease and Treatmenten_US
article.volume12en_US Mai Universityen_US Savang Vadhana Memorial Hospitalen_US Universityen_US Kaen Regional Hospitalen_US
Appears in Collections:CMUL: Journal Articles

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