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Title: Kaposi sarcoma risk in HIV-infected children and adolescents on combination antiretroviral therapy from sub-Saharan Africa, Europe, and Asia
Authors: Eliane Rohner
Kurt Schmidlin
Marcel Zwahlen
Rana Chakraborty
Gary Clifford
Niels Obel
Sophie Grabar
Annelies Verbon
Antoni Noguera-Julian
Ali Judd
Intira Jeannie Collins
Pablo Rojo
Norbert Brockmeyer
Maria Campbell
Geneviève Chene
Hans Prozesky
Brian Eley
D'Cristina Stefan
Alan Davidson
Cleophas Chimbetete
Shobna Sawry
Mary Ann Davies
Azar Kariminia
Ung Vibol
Annette Sohn
Matthias Egger
Julia Bohlius
Frank Tanser
Michael Vinikoor
Eusebio Macete
Robin Wood
Kathryn Stinson
Daniela Garone
Geoffrey Fatti
Sam Phiri
Janet Giddy
Kennedy Malisita
Christiane Fritz
Michael Hobbins
Kamelia Kamenova
Matthew Fox
Karl Technau
Robert Zangerle
Giota Touloumi
Josiane Warszawski
Laurence Meyer
François Dabis
Murielle Mary Krause
Jade Ghosn
Catherine Leport
Linda Wittkop
Peter Reiss
Ferdinand Wit
Maria Prins
Heiner Bucher
Caroline Sabin
Diana Gibb
Gerd Fätkenheuer
Julia Del Amo
Claire Thorne
Amanda Mocroft
Ole Kirk
Christoph Stephan
Santiago Pérez-Hoyos
Osamah Hamouda
Barbara Bartmeyer
Nikoloz Chkhartishvili
Andrea Antinori
Antonella D.Arminio Monforte
Luis Prieto
Antoni Soriano-Arandes
Manuel Battegay
Roger Kouyos
Cristina Mussini
Pat Tookey
Jordi Casabona
Jose M. Miró
Antonella Castagna
Deborah Konopnick
Tessa Goetghebuer
Anders Sönnerborg
Carlo Torti
Ramon Teira
Myriam Garrido
David Haerry
Stéphane De Wit
Dominique Costagliola
Dorthe Raben
Diana Barger
Christine Schwimmer
Monique Termote
Casper Frederiksen
Nina Friis-Møller
Juan Berenguer
Vincent Bouteloup
Alessandro Cozzi-Lepri
Maria Dorrucci
Keywords: Medicine
Issue Date: 1-Nov-2016
Abstract: © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. Background. The burden of Kaposi sarcoma (KS) in human immunodeficiency virus (HIV)-infected children and adolescents on combination antiretroviral therapy (cART) has not been compared globally. Methods. We analyzed cohort data from the International Epidemiologic Databases to Evaluate AIDS and the Collaboration of Observational HIV Epidemiological Research in Europe.We included HIV-infected children aged <16 years at cART initiation from 1996 onward. We used Cox models to calculate hazard ratios (HRs), adjusted for region and origin, sex, cART start year, age, and HIV/AIDS stage at cART initiation. Results. We included 24 991 children from eastern Africa, southern Africa, Europe and Asia; 26 developed KS after starting cART. Incidence rates per 100 000 person-years (PYs) were 86 in eastern Africa (95% confidence interval [CI], 55-133), 11 in southern Africa (95% CI, 4-35), and 81 (95% CI, 26-252) in children of sub-Saharan African (SSA) origin in Europe. The KS incidence rates were 0/100 000 PYs in children of non-SSA origin in Europe (95% CI, 0-50) and in Asia (95% CI, 0-27). KS risk was lower in girls than in boys (adjusted HR [aHR], 0.3; 95% CI, .1-.9) and increased with age (10-15 vs 0-4 years; aHR, 3.4; 95% CI, 1.2-10.1) and advanced HIV/AIDS stage (CDC stage C vs A/B; aHR, 2.4; 95% CI, .8-7.3) at cART initiation. Conclusions. HIV-infected children from SSA but not those from other regions, have a high risk of developing KS after cART initiation. Early cART initiation in these children might reduce KS risk.
ISSN: 15376591
Appears in Collections:CMUL: Journal Articles

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