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dc.contributor.authorNuthapong Ukarapolen_US
dc.contributor.authorPattara Khamrinen_US
dc.contributor.authorJiraporn Khoranaen_US
dc.contributor.authorJesda Singhavejsakulen_US
dc.contributor.authorAlisara Damrongmaneeen_US
dc.contributor.authorNiwat Maneekarnen_US
dc.description.abstract© 2016 Wiley Periodicals, Inc. The pathogenesis of intussusception without obvious anatomical leading points remains unclear. The objective of this study was to determine a feasibility of association between certain gastroenteritis viruses and intussusception. This was a prospective cohort study. Forty intussusception cases and 136 acute gastroenteritis controls with comparable age and gender were separately consecutively enrolled and relevant clinical data of both groups were recorded. The clinical specimens collected from all patients were screened for adenovirus, rotavirus, norovirus, and astrovirus by PCR and RT-PCR using specific primers. The genomes of detected viruses were characterized further to identify their genotypes by nucleotide sequencing. In 40 intussusception cases, adenovirus, rotavirus, and norovirus were detected in 12 (30.0%), 2 (5.0%), and 2 (5.0%), respectively while astrovirus was undetectable. In contrast, 136 acute gastroenteritis patients, adenovirus, rotavirus, and norovirus were detected in 11 (8.1%), 24 (17.7%), and 24 (17.7%) patients, respectively and again astrovirus was undetectable. The detection of adenovirus in intussusception patients was significantly higher than those in the control group (P < 0.001) with an odd ratio of 4.87 (95%CI: 1.95, 12.16). Interestingly, molecular analysis of adenovirus genome demonstrated that all of adenovirus detected in intussusception patients belonged to adenovirus C. This could be a potential risk factor or pathogenesis for developing intussusception in the cases of those without apparent anatomical leading points. J. Med. Virol. 88:1930–1935, 2016. © 2016 Wiley Periodicals, Inc.en_US
dc.subjectImmunology and Microbiologyen_US
dc.titleAdenovirus infection: A potential risk for developing intussusception in pediatric patientsen_US
article.title.sourcetitleJournal of Medical Virologyen_US
article.volume88en_US Mai Universityen_US
Appears in Collections:CMUL: Journal Articles

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