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|Title:||Ultrasound-assisted synthesis of substituted 2-aminobenzimidazoles, 2-aminobenzoxazoles, and related heterocycles|
|Keywords:||Biochemistry, Genetics and Molecular Biology|
Pharmacology, Toxicology and Pharmaceutics
|Abstract:||© 2016 Elsevier Ltd A sonochemical method for the synthesis of 2-aminobenzimidazoles and 2-aminobenzoxazoles, as well as chiral aminooxazolines and a chiral substituted quinazolin-5-one is reported. Using the Ph3P–I2system in the presence of triethylamine as a desulfurization agent, monothioureas prepared in situ from the reaction of bis-nucleophiles with isothiocyanates underwent rapid cyclization to afford a variety of N-heterocyclic compounds in good to excellent yields under mild conditions.|
|Appears in Collections:||CMUL: Journal Articles|
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