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Title: Ultrasound-assisted synthesis of substituted guanidines from thioureas
Authors: Mookda Pattarawarapan
Subin Jaita
Sirilak Wangngae
Wong Phakhodee
Keywords: Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics
Issue Date: 15-Jan-2016
Abstract: © 2016 Elsevier Ltd. Ultrasound-assisted synthesis of guanidine derivatives was developed using 2,4,6-trichloro-1,3,5-triazine as an inexpensive dehydrosulfurization reagent. Both 1,3-alkylaryl- and 1,3-diaryl-thioureas were rapidly converted into carbodiimides before subsequent reaction with aromatic or aliphatic amines. The method allows rapid access to highly substituted guanidines in good to excellent yields under mild conditions and with minimal use of solvent.
ISSN: 18733581
Appears in Collections:CMUL: Journal Articles

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