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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chiea Chuen Khor | en_US |
| dc.contributor.author | Tan Do | en_US |
| dc.contributor.author | Hongyan Jia | en_US |
| dc.contributor.author | Masakazu Nakano | en_US |
| dc.contributor.author | Ronnie George | en_US |
| dc.contributor.author | Khaled Abu-Amero | en_US |
| dc.contributor.author | Roopam Duvesh | en_US |
| dc.contributor.author | Li Jia Chen | en_US |
| dc.contributor.author | Zheng Li | en_US |
| dc.contributor.author | Monisha E. Nongpiur | en_US |
| dc.contributor.author | Shamira A. Perera | en_US |
| dc.contributor.author | Chunyan Qiao | en_US |
| dc.contributor.author | Hon Tym Wong | en_US |
| dc.contributor.author | Hiroshi Sakai | en_US |
| dc.contributor.author | Mônica Barbosa De Melo | en_US |
| dc.contributor.author | Mei Chin Lee | en_US |
| dc.contributor.author | Anita SChan | en_US |
| dc.contributor.author | Yaakub Azhany | en_US |
| dc.contributor.author | Thi Lam Huong Dao | en_US |
| dc.contributor.author | Yoko Ikeda | en_US |
| dc.contributor.author | Rodolfo A. Perez-Grossmann | en_US |
| dc.contributor.author | Tomasz Zarnowski | en_US |
| dc.contributor.author | Alexander C. Day | en_US |
| dc.contributor.author | Jost B. Jonas | en_US |
| dc.contributor.author | Pancy O.S. Tam | en_US |
| dc.contributor.author | Tuan Anh Tran | en_US |
| dc.contributor.author | Humaira Ayub | en_US |
| dc.contributor.author | Farah Akhtar | en_US |
| dc.contributor.author | Shazia Micheal | en_US |
| dc.contributor.author | Paul T.K. Chew | en_US |
| dc.contributor.author | Leyla A. Aljasim | en_US |
| dc.contributor.author | Tanuj Dada | en_US |
| dc.contributor.author | Tam Thi Luu | en_US |
| dc.contributor.author | Mona S. Awadalla | en_US |
| dc.contributor.author | Naris Kitnarong | en_US |
| dc.contributor.author | Boonsong Wanichwecharungruang | en_US |
| dc.contributor.author | Yee Yee Aung | en_US |
| dc.contributor.author | Jelinar Mohamed-Noor | en_US |
| dc.contributor.author | Saravanan Vijayan | en_US |
| dc.contributor.author | Sripriya Sarangapani | en_US |
| dc.contributor.author | Rahat Husain | en_US |
| dc.contributor.author | Aliza Jap | en_US |
| dc.contributor.author | Mani Baskaran | en_US |
| dc.contributor.author | David Goh | en_US |
| dc.contributor.author | Daniel H. Su | en_US |
| dc.contributor.author | Huaizhou Wang | en_US |
| dc.contributor.author | Vernon K. Yong | en_US |
| dc.contributor.author | Leonard W. Yip | en_US |
| dc.contributor.author | Tuyet Bach Trinh | en_US |
| dc.contributor.author | Manchima Makornwattana | en_US |
| dc.contributor.author | Thanh Thu Nguyen | en_US |
| dc.contributor.author | Edgar U. Leuenberger | en_US |
| dc.contributor.author | Ki Ho Park | en_US |
| dc.contributor.author | Widya Artini Wiyogo | en_US |
| dc.contributor.author | Rajesh SKumar | en_US |
| dc.contributor.author | Celso Tello | en_US |
| dc.contributor.author | Yasuo Kurimoto | en_US |
| dc.contributor.author | Suman S. Thapa | en_US |
| dc.contributor.author | Kessara Pathanapitoon | en_US |
| dc.contributor.author | John F. Salmon | en_US |
| dc.contributor.author | Yong Ho Sohn | en_US |
| dc.contributor.author | Antonio Fea | en_US |
| dc.contributor.author | Mineo Ozaki | en_US |
| dc.contributor.author | Jimmy S.M. Lai | en_US |
| dc.contributor.author | Visanee Tantisevi | en_US |
| dc.contributor.author | Chaw Chaw Khaing | en_US |
| dc.contributor.author | Takanori Mizoguchi | en_US |
| dc.contributor.author | Satoko Nakano | en_US |
| dc.contributor.author | Chan Yun Kim | en_US |
| dc.contributor.author | Guangxian Tang | en_US |
| dc.contributor.author | Sujie Fan | en_US |
| dc.contributor.author | Renyi Wu | en_US |
| dc.contributor.author | Hailin Meng | en_US |
| dc.contributor.author | Thi Thuy Giang Nguyen | en_US |
| dc.contributor.author | Tien Dat Tran | en_US |
| dc.contributor.author | Morio Ueno | en_US |
| dc.contributor.author | Jose Maria Martinez | en_US |
| dc.contributor.author | Norlina Ramli | en_US |
| dc.contributor.author | Yin Mon Aung | en_US |
| dc.contributor.author | Rigo Daniel Reyes | en_US |
| dc.contributor.author | Stephen A. Vernon | en_US |
| dc.contributor.author | Seng Kheong Fang | en_US |
| dc.contributor.author | Zhicheng Xie | en_US |
| dc.contributor.author | Xiao Yin Chen | en_US |
| dc.contributor.author | Jia Nee Foo | en_US |
| dc.date.accessioned | 2018-09-05T02:53:12Z | - |
| dc.date.available | 2018-09-05T02:53:12Z | - |
| dc.date.issued | 2016-05-01 | en_US |
| dc.identifier.issn | 15461718 | en_US |
| dc.identifier.issn | 10614036 | en_US |
| dc.identifier.other | 2-s2.0-84963502585 | en_US |
| dc.identifier.other | 10.1038/ng.3540 | en_US |
| dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84963502585&origin=inward | en_US |
| dc.identifier.uri | http://cmuir.cmu.ac.th/jspui/handle/6653943832/55215 | - |
| dc.description.abstract | © 2016 Nature America, Inc. Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study (GWAS) followed by replication in a combined total of 10,503 PACG cases and 29,567 controls drawn from 24 countries across Asia, Australia, Europe, North America, and South America. We observed significant evidence of disease association at five new genetic loci upon meta-analysis of all patient collections. These loci are at EPDR1 rs3816415 (odds ratio (OR) = 1.24, P = 5.94 × 10 -5), CHAT rs1258267 (OR = 1.22, P = 2.85 × 10 -6), GLIS3 rs736893 (OR = 1.18, P = 1.43 × 10 -4), FERMT2 rs7494379 (OR = 1.14, P = 3.43 × 10 -1), and DPM2-FAM102A rs3739821 (OR = 1.15, P = 8.32 × 10 -2). We also confirmed significant association at three previously described loci (P < 5 × 10 â'8 for each sentinel SNP at PLEKHA7, COL11A1, and PCMTD1-ST18), providing new insights into the biology of PACG. | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.title | Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma | en_US |
| dc.type | Journal | en_US |
| article.title.sourcetitle | Nature Genetics | en_US |
| article.volume | 48 | en_US |
| article.stream.affiliations | Genome Institute of Singapore | en_US |
| article.stream.affiliations | Duke-NUS Graduate Medical School Singapore | en_US |
| article.stream.affiliations | National University of Singapore | en_US |
| article.stream.affiliations | Vietnam National Institute of Ophthalmology | en_US |
| article.stream.affiliations | Beijing Tongren Hospital | en_US |
| article.stream.affiliations | Kyoto Prefectural University of Medicine | en_US |
| article.stream.affiliations | Medical Research Foundation, Chennai | en_US |
| article.stream.affiliations | King Saud University Medical College | en_US |
| article.stream.affiliations | University of Florida | en_US |
| article.stream.affiliations | Aravind Medical Research Foundation | en_US |
| article.stream.affiliations | Chinese University of Hong Kong | en_US |
| article.stream.affiliations | Tan Tock Seng Hospital | en_US |
| article.stream.affiliations | University of the Ryukyus | en_US |
| article.stream.affiliations | Universidade Estadual de Campinas | en_US |
| article.stream.affiliations | School of Medical Sciences - Universiti Sains Malaysia | en_US |
| article.stream.affiliations | Instituto de Glaucoma y Catarata | en_US |
| article.stream.affiliations | Medical University of Lublin | en_US |
| article.stream.affiliations | Moorfields Eye Hospital NHS Foundation Trust | en_US |
| article.stream.affiliations | UCL Institute of Ophthalmology | en_US |
| article.stream.affiliations | Universitat Heidelberg | en_US |
| article.stream.affiliations | Ho Chi Minh City Oncology Hospital | en_US |
| article.stream.affiliations | COMSATS Institute of Information Technology | en_US |
| article.stream.affiliations | Al-Shifa Trust Eye Hospital | en_US |
| article.stream.affiliations | Radboud University Nijmegen Medical Centre | en_US |
| article.stream.affiliations | National University Health System | en_US |
| article.stream.affiliations | King Khaled Eye Specialist Hospital | en_US |
| article.stream.affiliations | All India Institute of Medical Sciences, New Delhi | en_US |
| article.stream.affiliations | Da Nang Eye Hospital | en_US |
| article.stream.affiliations | Flinders University | en_US |
| article.stream.affiliations | Mahidol University | en_US |
| article.stream.affiliations | Rajavithi Hospital | en_US |
| article.stream.affiliations | Rangsit University | en_US |
| article.stream.affiliations | University of Medicine-Mandalay | en_US |
| article.stream.affiliations | Kuala Lumpur Hospital | en_US |
| article.stream.affiliations | Vision Research Foundation India | en_US |
| article.stream.affiliations | Changi General Hospital | en_US |
| article.stream.affiliations | Faculty of Medicine, Thammasat University | en_US |
| article.stream.affiliations | Viet Tiep General Hospital | en_US |
| article.stream.affiliations | Asian Eye Institute | en_US |
| article.stream.affiliations | University of the East, Philippines | en_US |
| article.stream.affiliations | Seoul National University | en_US |
| article.stream.affiliations | Jakarta Eye Center | en_US |
| article.stream.affiliations | Universitas Indonesia | en_US |
| article.stream.affiliations | Narayana Nethralaya Eye Hospital | en_US |
| article.stream.affiliations | New York Eye and Ear Infirmary | en_US |
| article.stream.affiliations | Kobe City Medical Center General Hospital | en_US |
| article.stream.affiliations | Tilganga Institute of Ophthalmology | en_US |
| article.stream.affiliations | Chiang Mai University | en_US |
| article.stream.affiliations | University of Oxford | en_US |
| article.stream.affiliations | Konyang University | en_US |
| article.stream.affiliations | Universita degli Studi di Torino | en_US |
| article.stream.affiliations | Ozaki Eye Hospital | en_US |
| article.stream.affiliations | University of Miyazaki | en_US |
| article.stream.affiliations | The University of Hong Kong | en_US |
| article.stream.affiliations | Chulalongkorn University | en_US |
| article.stream.affiliations | No. 1 Defence Services General Hospital | en_US |
| article.stream.affiliations | Mizoguchi Eye Clinic | en_US |
| article.stream.affiliations | Oita University | en_US |
| article.stream.affiliations | Yonsei University | en_US |
| article.stream.affiliations | Shijiazhuang First Eye Hospital | en_US |
| article.stream.affiliations | Handan Eye Hospital | en_US |
| article.stream.affiliations | Xiamen University | en_US |
| article.stream.affiliations | Anyang Eye Hospital | en_US |
| article.stream.affiliations | Pasig City General Hospital | en_US |
| article.stream.affiliations | University of Malaya | en_US |
| article.stream.affiliations | Pun Hlaing Silom Hospital | en_US |
| article.stream.affiliations | Shwe La Min Hospital | en_US |
| article.stream.affiliations | Asian Hospital and Medical Center, Muntinlupa | en_US |
| article.stream.affiliations | Binan Doctors Hospital | en_US |
| article.stream.affiliations | Nottingham University Hospitals NHS Trust | en_US |
| article.stream.affiliations | BMI Park Hospital | en_US |
| article.stream.affiliations | International Specialist Eye Centre | en_US |
| article.stream.affiliations | Aravind Eye Hospital | en_US |
| Appears in Collections: | CMUL: Journal Articles | |
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