Please use this identifier to cite or link to this item: http://cmuir.cmu.ac.th/jspui/handle/6653943832/55206
Title: Anticlastogenicity and Anticarcinogenicity of Purple Rice Extract in Rats
Authors: Charatda Punvittayagul
Paweena Sankam
Sirinya Taya
Rawiwan Wongpoomchai
Keywords: Biochemistry, Genetics and Molecular Biology
Medicine
Nursing
Issue Date: 18-May-2016
Abstract: © 2016 Taylor & Francis Group, LLC. Oryza sativa L. var. indica cv. Kum Doi Saket is a pigmented rice variety grown in northern Thailand. Our previous study found that the methanol extract of purple rice seed had the highest level of antimutagenicity in a Salmonella mutation assay. The present study was designed to evaluate its in vivo anticlastogenic and anticarcinogenic potentials. The purple rice extract had no acute toxicity on rats. The oral administration of 1,000 mg/kg body weight (bw) of the extract for 28 days did not increase the number of micronucleated hepatocytes. Interestingly, it significantly reduced the amount of micronucleus formation in the liver of diethylnitrosamine (DEN)-treated rats. The inhibitory mechanism involved the induction of hepatic glutathione S-transferase (GST) activity. In addition, oral administration of 500 mg/kg bw extract for 10 weeks significantly decreased the number of hepatic GST placental form positive foci, but did not modulate the number of colonic aberrant crypt foci in DEN- and dimethylhydrazine-initiated rats. In conclusion, the methanol extract of purple rice seed showed no toxicity, clastogenicity, or carcinogenicity in laboratory rats. It did display chemopreventive activity against the early stages of rat hepatocarcinogenesis.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84966727858&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/55206
ISSN: 15327914
01635581
Appears in Collections:CMUL: Journal Articles

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