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Title: Efavirenz concentrations and probability of HIV replication in children
Authors: Nontiya Homkham
Tim R. Cressey
Naïm Bouazza
Chulapong Chanta
Linda Aurpibul
Thition Narkbunnam
Sawitree Krikajornkitti
Nareerat Kamonpakorn
Marc Lallemant
Lily Ingsrisawang
Nicolas Salvadori
Jean Marc Treluyer
Saik Urien
Gonzague Jourdain
Keywords: Medicine
Issue Date: 1-Jan-2015
Abstract: Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. In 188 HIV-infected children receiving efavirenz, a lower middose (C12) was associated with a higher risk of HIV-1 viral load >400 copies/ mL (P = 0.03). Simulations for a normalized population receiving US Food and Drug Administration weight-band dosing predicted that 15% of children would have a C12 below target threshold (<1.0 mg/L) with a 23% risk of viral replication.
ISSN: 15320987
Appears in Collections:CMUL: Journal Articles

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