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dc.contributor.authorMonica Gandhien_US
dc.contributor.authorDavid V. Gliddenen_US
dc.contributor.authorAlbert Liuen_US
dc.contributor.authorPeter L. Andersonen_US
dc.contributor.authorHoward Horngen_US
dc.contributor.authorPatricia Defechereuxen_US
dc.contributor.authorJuan V. Guaniraen_US
dc.contributor.authorBeatriz Grinsztejnen_US
dc.contributor.authorSuwat Chariyalertsaken_US
dc.contributor.authorLinda Gail Bekkeren_US
dc.contributor.authorRobert M. Granten_US
dc.description.abstract© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. Self-reported adherence to pre-exposure prophylaxis (PrEP) has limitations, raising interest in pharmacologic monitoring. Drug concentrations in hair and dried blood spots (DBS) are used to assess long-term-exposure; hair shipment/storage occurs at room temperature. The iPrEx Open Label Extension collected DBS routinely, with opt-in hair collection; concentrations were measured with liquid chromatography/tandem mass spectrometry. In 806 hair-DBS pairs, tenofovir (TFV) hair levels and TFV diphosphate (DP) in DBS were strongly correlated (Spearman coefficient r = 0.734; P <. 001), as were hair TFV/DBS emtricitabine (FTC) triphosphate (TP) (r = 0.781; P <. 001); hair FTC/DBS TFV-DP (r = 0.74; P <. 001); hair FTC/DBS FTC-TP (r = 0.587; P <. 001). Drug detectability was generally concordant by matrix. Hair TFV/FTC concentrations correlate strongly with DBS levels, which are predictive of PrEP outcomes.en_US
dc.titleStrong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension: Implications for pre-exposure prophylaxis adherence monitoringen_US
article.title.sourcetitleJournal of Infectious Diseasesen_US
article.volume212en_US of California, San Franciscoen_US Francisco Department of Public Healthen_US J. David Gladstone Institutesen_US of Colorado at Denveren_US Medicas en Saluden_US Oswaldo Cruzen_US Mai Universityen_US of Cape Townen_US
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